Evidence map›Paper›PMID 42083646›Full record

ArticleBioinformatics advances2026

Covariate balanced allocation of samples to batches to mitigate the impacts of technical variability.

John F Mulvey, Alicia Lundby

Abstract read
In one paragraph

Article in Bioinformatics advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John F MulveyDepartment of Biomedical Sciences, University of Copenhagen, Faculty of Health and Medical Sciences, Denmark.ORCID https://orcid.org/0000-0003-3843-2442
Alicia LundbyDepartment of Biomedical Sciences, University of Copenhagen, Faculty of Health and Medical Sciences, Denmark.ORCID https://orcid.org/0000-0002-1612-6041

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motivation: Performing assays on large numbers of samples requires their analysis in distinct batches, which commonly affects the measurements made in a systematic way. Analytical approaches can correct for such batch effects, however for this to be possible the batch should not be confounded with either the independent variable or any covariates relevant to the analysis. Thus, how samples are distributed across batches influences subsequent analytic conclusions. Results: We present Availability and implementation:

Identifiers

PMID42083646
PMCPMC13135629

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.