Evidence map›Paper›PMID 42083632›Full record

ArticleJournal of cell communication and signaling2026

Integrative genomic and functional characterization of ADAMTS3 reveals its inflammatory regulation via NF-κB and STAT3 pathways in osteosarcoma.

Ehed Muhammed Aymaz, Meltem Alper, Feyza Nur Sav, Tuğşen Aydemir, Feray Köçkar

Abstract read
In one paragraph

Article in Journal of cell communication and signaling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ehed Muhammed Aymazİstinye University Graduate Education Institute Molecular Oncology Istanbul Turkey.ORCID https://orcid.org/0009-0006-7337-1365
Meltem AlperDepartment of Translational Oncology Dokuz Eylul University Institute of Oncology Izmir Turkey.ORCID https://orcid.org/0000-0001-6359-9979
Feyza Nur SavFaculty of Science and Literature Department of Molecular Biology and Genetics Balikesir University Balikesir Turkey.ORCID https://orcid.org/0000-0003-3506-1068
Tuğşen AydemirCell Therapy Department Moffitt Cancer Center and Research Institute Tampa Florida USA.ORCID https://orcid.org/0000-0003-2803-4782
Feray KöçkarFaculty of Science and Literature Department of Molecular Biology and Genetics Balikesir University Balikesir Turkey.ORCID https://orcid.org/0000-0003-2572-8391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteosarcoma (OS) is an aggressive bone malignancy characterized by genomic instability and extensive extracellular matrix (ECM) remodeling. Members of the

Indexed as

ADAMTS‐3extracellular matrix remodelingNF‐κB and STAT3 transcription factorsosteosarcomatumor necrosis factor‐alpha (TNF‐α) signaling pathway

Identifiers

PMID42083632
PMCPMC13135670

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.