ArticleOpen life sciences2026
KIF14-AKT axis regulates ferroptosis sensitivity in triple-negative breast cancer.
Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited targeted treatment options. Ferroptosis has emerged as a potential therapeutic vulnerability in TNBC, but its upstream regulation remains incompletely defined. Here, we combined bioinformatics analysis with cell-based experiments to investigate the role of kinesin family member 14 (KIF14) in ferroptosis sensitivity. KIF14 was upregulated in TNBC datasets and associated with poor prognosis. In MDA-MB-468 cells, KIF14 knockdown reduced cell viability, increased malondialdehyde and intracellular Fe
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