Evidence map›Paper›PMID 42083407›Full record

ReviewCurrent aging science2026

Plant-derived Secondary Metabolites that Delay Dermal Aging in Humans Through Longevity Pathways.

Nipuni Dilanka Hennadige, Thisanja Cooray, Shalini Wijerathne, Nishadi Rathnayake, Sanadie Gamage, Nirmal Perera, Umapriyatharshini Rajagopalan, Poorna Piyathilake, Kamani Tennekoon, Prasanna Galhena and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current aging science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nipuni Dilanka HennadigeInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Thisanja CoorayInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Shalini WijerathneInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Nishadi RathnayakeInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Sanadie GamageInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Nirmal PereraInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Umapriyatharshini RajagopalanInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Poorna PiyathilakeDepartment of Environmental Technology, Faculty of Technology, University of Colombo. Mahenwatta, Pitipana, Thalagala Road, Homagama, Sri Lanka.
Kamani TennekoonInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Prasanna GalhenaInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Kanishka SenathilakeInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.
Sameera R SamarakoonInstitute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin is the largest organ of the human body and is one of the organs most affected by aging, contributing to the appearance associated with old age. Skin aging, also known as dermal aging, is influenced by both genetic and environmental factors. Plant secondary metabolites provide a potent source of diverse natural compounds with many pharmaceutical and biological activities, which offer promising anti-aging benefits. These plant-derived secondary metabolites have the potential to delay or decrease dermal aging by modulating key molecular players such as MMP, p53, p21, mTOR, and TGF-β. Activation or deactivation of these molecular players may accelerate or decelerate the aging process, respectively, and thereby exert direct effects on longevity. This narrative review begins with an introduction to the basic cellular concepts of dermal aging, then delves into the hallmarks of aging and discusses the different types of known plant-derived secondary metabolites, highlighting the mechanisms by which they delay dermal aging.

Indexed as

LongevityPlant ExtractsSkinSkin AgingAnimalsHumansSignal TransductionPlant Extractsanti-agingDermal aginghallmarks of agingmolecular players of agingplantssecondary metabolites

Identifiers

PMID42083407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.