Evidence map›Paper›PMID 42083390›Full record

ArticleJournal of veterinary pharmacology and therapeutics2026

Pharmacokinetic Profiles of Enrofloxacin and Its Metabolite Ciprofloxacin Administered by Different Doses in Calves.

Kamil Uney, Orhan Corum, Murat Yuksel, Mario Giorgi, Pedro Marin, Duygu Durna Corum, Amnart Poapolathep, Saranya Poapolathep, Halis Oguz, Enver Yazar and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kamil UneyDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Türkiye.ORCID https://orcid.org/0000-0002-8674-4873
Orhan CorumDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Türkiye.ORCID https://orcid.org/0000-0003-3168-2510
Murat YukselDepartment of Obstetrics and Gyneacology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Türkiye.ORCID https://orcid.org/0000-0001-6634-0559
Mario GiorgiDepartment of Veterinary Sciences, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0003-3657-4703
Pedro MarinDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Murcia, Spain.
Duygu Durna CorumDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Türkiye.ORCID https://orcid.org/0000-0003-1567-991X
Amnart PoapolathepDepartment of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.ORCID https://orcid.org/0000-0001-5322-3281
Saranya PoapolathepDepartment of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Halis OguzDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Türkiye.ORCID https://orcid.org/0000-0002-9236-0630
Enver YazarDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Türkiye.
Muammer ElmasDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Türkiye.ORCID https://orcid.org/0000-0001-9059-7151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research studied dose-dependent changes in the pharmacokinetics of enrofloxacin (ENR) and its active metabolite, ciprofloxacin (CIP), in calves. The research was performed on eighteen calves utilizing a parallel pharmacokinetic approach. Calves were divided into three distinct dosage groups, receiving intravenous administration of ENR at doses of 2.5, 5, and 10 mg/kg, respectively. Blood samples were collected at 15 specified intervals during a 48-h duration. ENR and CIP plasma concentrations were quantified by HPLC. Pharmacokinetic data was obtained using non-compartmental analysis. The area under the concentration-time curve from 0 to last (AUC

Indexed as

Anti-Bacterial AgentsCiprofloxacinEnrofloxacinFluoroquinolonesAnimalsArea Under CurveCattleDose-Response Relationship, DrugHalf-LifeMaleAnti-Bacterial AgentsCiprofloxacinEnrofloxacinFluoroquinolonesascending dosecalvesciprofloxacinenrofloxacinHPLCpharmacokinetics

Identifiers

PMID42083390
PMCPMC13552512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.