ReviewJournal of neurochemistry2026
Chromaffin Versus Platelet Granules: What We Have Learned From Chromaffin Cells for Human Studies.
Review in Journal of neurochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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1 author.
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Abstract
Biological amines-such as dopamine, norepinephrine, epinephrine, octopamine, serotonin, and histamine-are stored at high concentrations within secretory vesicles, also referred to as "granules" in certain cell types, including mast cells, chromaffin cells, and platelets. Over the past decades, extensive knowledge has been gained regarding the biogenesis, composition, and function of chromaffin granules. This information can now be leveraged to understand amine storage mechanisms in other secretory systems, particularly in human platelets, which are readily accessible. Importantly, dysfunction of secretory vesicles has been implicated in several diseases, and vesicular defects may therefore be detectable in platelets obtained from well-characterized individuals. Such an approach offers significant potential for clinical and translational studies, as personalized functional information can be directly derived from patients. In this brief review, I focus on the vesicular mechanisms involved in biological amine accumulation and discuss the functional consequences of their disruption, with particular emphasis on chromaffin granules and platelet δ-granules.
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