ArticleChemSusChem2026
Safe and Sustainable by Design (SSbD) Synthesis of Food and Personal Care Ingredients by Mechanochemistry.
Article in ChemSusChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The preparation of perillartine, a potent marketed sweetener, and N-tert-butyl-α-phenylnitrone (PBN), a most commonly used free-radical spin-trap used in personal care formulation, endowed with antioxidant, neuroprotective, and anti-aging properties, was studied by vibrating and planetary ball-milling. The reactivity in polymeric jars, such as PTFE and in-house made polyoxymethylene (POM), was evaluated and compared to the most commonly used stainless steel and zirconium oxide milling media. This investigation revealed an insightful correlation while also accounting for the energy involved in each transformation. Assessment of the processes by green chemistry metrics and tools (e.g., Chem21, DOZN 3.0 and EcoScale) showed that mechanochemical approaches offer a Safe and Sustainable by Design (SSbD) approach also complying with the IUPAC guiding principles of a responsible chemistry. The reduced solvent consumption, the simplified purification procedures, and lower associated environmental and safety hazards are strongly aligned with the green chemistry principles.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.