Evidence map›Paper›PMID 42083301›Full record

ArticleCancer medicine2026

Diagnostic Utility of a Cost-Effective Four-Gene Next Generation Sequencing Panel for Predicting Papillary Thyroid Carcinoma in Indeterminate Thyroid Cytology: A Multicenter Study in China.

Qiong Jiao, Ling Wu, Bing Wei, Qing Li, Xuling Su, Keyang Sun, Xiaoyue Zhang, Yanli Luo, Zhiyan Liu

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiong JiaoDepartment of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-8952-4019
Ling WuDepartment of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bing WeiDepartment of Molecule and Pathology, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.
Qing LiThe Third Affiliated Hospital of Soochow University, Changzhou First People's Hospital, Changzhou, China.ORCID https://orcid.org/0000-0003-4661-3681
Xuling SuDepartment of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-3754-9457
Keyang SunDepartment of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoyue ZhangShanghai RIGEN Biotechnology co., Ltd., Shanghai, China.
Yanli LuoDepartment of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-3606-4658
Zhiyan LiuDepartment of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-9668-7756

Funding

Demonstration program for innovative medical devices and drugs of Shanghai Municipality 25SF1906305National Natural Science Foundation of China 82472629Nature Science Fund of Science and Technology Commission of Shanghai Municipality 23ZR1448200Noncommunicable Chronic Diseases-National Science and Technology Major Project of China 2024ZD0525600Shanghai Leading Talent Program of Eastern Talent Plan BJWS2025042
6 · The paper itself

Abstract

Molecular testing has emerged as a pivotal tool for the preoperative assessment of cytologically indeterminate thyroid nodules. In this cross-sectional study, we evaluated the diagnostic utility of a targeted next-generation sequencing (NGS) 4-gene panel, including BRAF

Indexed as

Biomarkers, TumorHigh-Throughput Nucleotide SequencingThyroid Cancer, PapillaryThyroid NeoplasmsThyroid NoduleAdultBiopsy, Fine-NeedleChinaCost-Benefit AnalysisCross-Sectional StudiesFemaleHumansMaleMiddle AgedMutationPromoter Regions, GeneticBiomarkers, TumorBRAF protein, humanNTRK3 protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-retReceptor, trkCRET protein, humanTelomeraseTERT protein, human

Identifiers

PMID42083301
PMCPMC13139720

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.