Trial reportAddiction science & clinical practice2026
Microcosting the optimization of PrEP implementation among sexual and gender minority individuals with a substance use disorder.
Trial report in Addiction science & clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05934877 (Optimizing PrEP Implementation and Cost-effectiveness Among Sexual and Gender Minority Individuals With a Substance Use Disorder), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing PrEP Implementation and Cost-effectiveness Among Sexual and Gender Minority Individuals With a Substance Use Disorder
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aimSubstance Use Disorder (SUD) increases HIV risk and is often a barrier to advancement along the PrEP Care Continuum. In the United States ~ 40,000 new HIV diagnoses occur annually, the majority among sexual and gender minorities who use substances. Insufficiently treated HIV and SUD results in substantial costs to society. Effective strategies that focus on SUD as part of a client-centered approach to improve PrEP engagement and address social determinants of health (SDoH), are critical. Understanding resources/cost requirements is important to know for prospective sites.
methodsThe parent R01 was a single-site, randomized stepped-care and cost-effectiveness trial of Assisted Service Knowledge (A.S.K)-PrEP vs. standard of care (SOC), where "non-responders" in the A.S.K-PrEP arm were stepped to additional attention for SUD via contingency management (CM), resulting in three strategies against SOC (A.S.K-PrEP; A.S.K-PrEP + CM; A.S.K-PrEPàCM alone). Resources needed to implement and sustain each strategy were captured as part of a detailed microcosting analysis. Resources were categorized as fixed start-up, time-dependent, or variable, and organized within the implementation or sustainment phase. Costs were assigned using nationally representative prices.
resultsStart-up costs (first year costs) were $25,958 and time-dependent costs (annually based) were $68,442 across strategies. Variable costs (annually based) differed across strategies resulting in $31,716 for A.S.K-PrEP alone, $31,994 for A.S.K-PrEP + CM and $30,271 for CM alone. The per-participant intervention cost was $55 for Standard of Care, $104 for A.S.K-PrEP alone, $73 for A.S.K-PrEP + CM, and $16 for CM alone.
conclusionThis study provides key insights into the "real-world" resource/cost requirements for implementing and sustaining each A.S.K.-PrEP strategy. Our results and publicly available budget impact tool provide support for potential stakeholders to ensure both feasibility and long-term sustainability for PrEP uptake and adherence for sexual and gender minority individuals with a SUD. TRIAL REGISTRATION NUMBER: NCT05934877 and was registered on 05/23/23 as a clinical trial.
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