Evidence map›Paper›PMID 42082929›Full record

ArticleBMC neurology2026

Association of antibodies against neural antigens with futile reperfusion in patients with anterior circulation large vessel occlusion ischemic stroke after endovascular treatment: a cohort study.

Bin Gao, Shuwen Wang, Nannan Han, Jinwei Duan, Shilin Li, Gejuan Zhang, Mingze Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Bin GaoDepartment of Neurology, the Affiliated Hospital of Northest University, Xi'an No.3 Hospital, Xi'an, No. 10, East Section, Fengcheng 3rd Road, Weiyang District, Xi'an, 710018, P.R. China.
Shuwen WangDepartment of Neurology, the Affiliated Hospital of Northest University, Xi'an No.3 Hospital, Xi'an, No. 10, East Section, Fengcheng 3rd Road, Weiyang District, Xi'an, 710018, P.R. China.
Nannan HanDepartment of Neurology, the Affiliated Hospital of Northest University, Xi'an No.3 Hospital, Xi'an, No. 10, East Section, Fengcheng 3rd Road, Weiyang District, Xi'an, 710018, P.R. China.
Jinwei DuanDepartment of Clinical Medical Research Center, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710018, China.
Shilin LiDepartment of Neurology, the Affiliated Hospital of Northest University, Xi'an No.3 Hospital, Xi'an, No. 10, East Section, Fengcheng 3rd Road, Weiyang District, Xi'an, 710018, P.R. China.
Gejuan ZhangDepartment of Neurology, the Affiliated Hospital of Northest University, Xi'an No.3 Hospital, Xi'an, No. 10, East Section, Fengcheng 3rd Road, Weiyang District, Xi'an, 710018, P.R. China.
Mingze ChangDepartment of Neurology, the Affiliated Hospital of Northest University, Xi'an No.3 Hospital, Xi'an, No. 10, East Section, Fengcheng 3rd Road, Weiyang District, Xi'an, 710018, P.R. China. changmingze191@163.com.ORCID http://orcid.org/0000-0002-8036-3877

Funding

Key Medical Research Program of Xi'an Municipal Bureau of Science and Technology 2024JH-YXZD-0054Medical Research Program, Xi'an Third Hospital Y2023yxyj06the Major Research projects of Xi'an, Shaanxi 21YXYJ0004
6 · The paper itself

Abstract

backgroundThe prevalence and titer patterns of anti-neuronal antibodies in patients with large vessel occlusion (LVO) strokes remain unclear. The relationship between anti-neuronal antibodies and ischemic stroke prognosis remains debated. This cohort study aimed to clarify the prevalence and titer characteristics of anti-neuronal antibodies in patients with anterior circulation LVO stroke and to examine their effect on outcomes following endovascular treatment.

methodWe retrospectively analyzed data from consecutive patients with first-ever acute ischemic stroke due to anterior circulation LVO admitted to Xi'an No. 3 Hospital (China) between November 2019 and September 2023. Logistic regression and propensity score matching were utilized to explore the relationship between anti-neuronal antibodies and outcomes in anterior circulation LVO stroke patients. Sensitivity analysis was conducted by calculating E-values and adjusting the caliper width for propensity score matching.

resultsAmong 153 patients, 28 tested positive for antibodies against neuronal antigens, with anti-N-methyl-D-aspartate receptor 1 (NMDAR1)-IgM being the most common. Anti-dipeptidyl-peptidase (DPPX)-IgG showed the highest titers, while anti-NMDAR1-IgM was predominantly low-titer. The presence of anti-neuronal antibodies is significantly and negatively correlated with a favorable prognosis following endovascular treatment in stroke patients with anterior circulation LVO. (ORs: 0.12-0.28, all p < 0.05). E-values ranged from 3.19 to 5.22, and adjusting the caliper to 0.1 confirmed the robustness of the study's findings.

conclusionsAnti-neuronal antibodies may be associated with an increased risk of futile recanalization in patients with anterior-circulation large-vessel occlusion stroke.

Indexed as

AutoantibodiesBrain IschemiaEndovascular ProceduresIschemic StrokeAgedCohort StudiesFemaleHumansMaleMiddle AgedReperfusionRetrospective StudiesAutoantibodiesAnterior circulationAnti - neuronal antibodiesEndovascular treatmentFutile reperfusionIschemic strokePropensity score matching

Identifiers

PMID42082929
PMCPMC13289504

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.