Evidence map›Paper›PMID 42082858›Full record

Trial reportOral radiology2026

A novel dual-energy cone beam computed tomography device for assessment of jaw bone density.

Vidhya Venkateswaran, Ritu Tiwari, Tara Aghaloo, Reuben Kim, Olga Bezouglaia, Sanjay M Mallya

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Oral radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04686084 (A Clinical Trial to Evaluate the Effectiveness and Safety of Dual Energy Cone-Beam Computed Tomography), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04686084 nacompletednot on this map

A Clinical Trial to Evaluate the Effectiveness and Safety of Dual Energy Cone-Beam Computed Tomography (DE-CBCT) Imaging for Quantitative Measurement of Jaw Bone Density

TypeinterventionalSponsorUniversity of California, Los AngelesRan2021 to 2021Enrolled26ConditionsDental DiseasesArmsDual-energy computed tomography scan
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vidhya VenkateswaranSection of Oral and Maxillofacial Radiology, School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
Ritu TiwariSection of Oral and Maxillofacial Radiology, School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
Tara AghalooSection of Oral and Maxillofacial Surgery, School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
Reuben KimSection of Restorative Dentistry, School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
Olga BezouglaiaSection of Oral and Maxillofacial Radiology, School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
Sanjay M MallyaSection of Oral and Maxillofacial Radiology, School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA. smallya@dentistry.ucla.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCone beam computed tomography (CBCT) provides morphological details of the dental hard tissues and bone. However, the relationship between object density and CBCT grey values is unreliable and limits application of CBCT for quantitative evaluation of bone density. This single center, open-label clinical trial investigated the validity of novel dual-energy CBCT device (DE-CBCT) to assess jaw bone density.

methodsThe study analyses comprised 24 subjects who were examined with DE-CBCT and multidetector CT (MDCT)-an established standard for bone density assessment. MDCT and DE-CBCT scans of each subject were analyzed in the vendor's software application for assessment of bone density at 10 discrete sites in the jaws. Two independent assessments were made.

resultsThe mean bone density assessed by DE-CBCT and MDCT were not significantly different (0.46 ± 0.36 g/cc versus 0.48 ± 0.31 g/cc, respectively). Bone density assessments from DE-CBCT correlated well with MDCT assessments (Pearson's correlation r = 0.92, p < 0.0001). Bland-Altman analyses demonstrated higher agreement between the two techniques at densities great than 0.6 g/cm

conclusionsDE-CBCT is a promising approach to assess bone density in the jaw bones. The investigational device performs best in well-trabeculated and cortical bone, with reduced reliability in sparsely trabeculated regions. Future refinements in this technology will be needed to expand the range of reliability for reliable assessment of bone density. CLINICAL TRIALS REGISTRATION: The study is registered in clinical trials.gov, NCT04686084.

Indexed as

Bone DensityCone-Beam Computed TomographyJawAdultAgedFemaleHumansMaleMiddle AgedMultidetector Computed TomographyReproducibility of ResultsCone beam computed tomographyDual-energy computed tomographyDual-energy cone beam computed tomographyJaw bone densitySpectral computed tomographySpectral cone beam computed tomography

Identifiers

PMID42082858
PMCPMC13619641

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.