Evidence map›Paper›PMID 42082844›Full record

Trial reportJournal of general internal medicine2026

Barriers to Medication Adherence and Mild Cognitive Impairment Among African Americans with Persistently Uncontrolled Hypertension: A Cross-sectional Analysis from the Southeastern Collaboration Trial.

Sunidhi Singh, Joanna Bryan Ringel, Elizabeth Baquero, Doyle M Cummings, Jacqueline Halladay, Andrea L Cherrington, Lynn Andreae, Monika Safford

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of general internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sunidhi SinghWeill Cornell Medicine, New York, NY, USA.
Joanna Bryan RingelDivision of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Elizabeth BaqueroDivision of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Doyle M CummingsDepartment of Family Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Jacqueline HalladayDepartment of Family Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Andrea L CherringtonDepartment of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Lynn AndreaeDepartment of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Monika SaffordWeill Cornell Medicine, New York, NY, USA. mms9024@med.cornell.edu.ORCID 0000-0002-3060-0563

Funding

NHLBI NIH HHS 130691
6 · The paper itself

Abstract

backgroundMild cognitive impairment (MCI) is frequently undetected and may lead to medication nonadherence. We examined whether more reported barriers to medication adherence could signal the presence of MCI.

objectiveWe developed a count of barriers (0, 1, 2, and ≥3) and determined the independent association between a greater number of barriers and odds of MCI.

settingRural primary care practices in Alabama and North Carolina.

participantsOne thousand two hundred seventy-nine participants of the Southeastern Collaboration to Improve Blood Pressure Control trial; all were African Americans with persistently uncontrolled hypertension. MAIN MEASURE: Presence of mild cognitive impairment (MCI).

resultsParticipants reporting ≥ 2 barriers had 2.40 (95% CI 1.03-5.75) times higher adjusted odds of MCI compared to those reporting none; those reporting ≥ 3 barriers had 3.80 (95% CI 1.74-8.31) higher odds. As the number of barriers increased, odds of MCI increased (p for trend < 0.001).

conclusionBarriers to medication adherence may signal MCI.

Indexed as

Antihypertensive AgentsBlack or African AmericanCognitive DysfunctionDrug MonitoringHypertensionMedication AdherenceAgedAlabamaCross-Sectional StudiesFemaleHumansMaleMiddle AgedNorth CarolinaAntihypertensive Agentscognitive impairmenthypertensionmedication adherence

Identifiers

PMID42082844
PMCPMC13569766

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.