ArticleBiological trace element research2026
The Chronic Metabolic Fingerprint of Canine Anxiety: Hair Trace Element Dyshomeostasis and the Dissociation of Behavioral Recovery via Hericium erinaceus.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Canine anxiety is a complex welfare issue involving neuro-endocrine dysregulation. While acute stress biomarkers are widely used, the chronic metabolic consequences of anxiety remain under-investigated. Hair mineral analysis offers a retrospective window into long-term systemic homeostasis. This study aimed to identify chronic trace element signatures in the hair of anxious dogs compared to healthy controls and evaluate whether behavioral recovery induced by Hericium erinaceus supplementation is reflected in the hair mineral matrix. Hair samples from 21 healthy controls and 8 clinically anxious dogs were analyzed for a 16-element panel (Zn, Cu, Fe, Mg, Mn, Se, Ni, Si, Ca, P, Al, Cd, Cr, As, B, and Pb) using ICP-OES. The anxious cohort received H. erinaceus extract (1000 mg/10 kg) daily for 28 days. Anxious dogs exhibited a distinct dyshomeostatic profile characterized by significantly higher hair zinc and aluminum, alongside a profound depletion of nickel (p < 0.001) and significantly elevated phosphorus (P) levels (p = 0.003). Supplementation led to a substantial 62% reduction in anxiety scores (p = 0.002), and post-treatment scores were no longer statistically different from those of the control group. However, most hair mineral concentrations remained stable post-treatment, with the notable exception of a significant increase in calcium (Ca) levels (p = 0.012). Furthermore, Spearman's correlation analysis revealed that higher anxiety severity was strongly and negatively associated with hair iron (Fe) and chromium (Cr) levels (r
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