Evidence map›Paper›PMID 42082769›Full record

ArticleJournal of cancer research and clinical oncology2026

Expression and clinical significance of cytochrome b561 in endometrial cancer.

Hao Lei, Hongyuan Liao, Zheng An, Xueyue Li, Xiude Li, Jing Hu, Xiaofeng Zhou

Abstract read
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Article in Journal of cancer research and clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Hao LeiGraduate School, Qinghai University, Xining, 810001, Qinghai, People's Republic of China.
Hongyuan LiaoGraduate School, Qinghai University, Xining, 810001, Qinghai, People's Republic of China.
Zheng AnPathology Department, Qinghai Women and Children's Hospital, Xining, 810007, Qinghai, People's Republic of China.
Xueyue LiGraduate School, Qinghai University, Xining, 810001, Qinghai, People's Republic of China.
Xiude LiGraduate School, Qinghai University, Xining, 810001, Qinghai, People's Republic of China.
Jing HuGraduate School, Qinghai University, Xining, 810001, Qinghai, People's Republic of China.
Xiaofeng ZhouDepartment of Pathology, Qinghai University Affiliated Hospital, Xining, 810001, Qinghai, People's Republic of China. ariel8001@163.com.

Funding

Qinghai Province"Kunlun Talents High-end Innovation and Entrepreneurial Talents"Top Talent Proiect 2024the Department of Science and Technology of Qinghai Province in China 2024-SF-L01
6 · The paper itself

Abstract

objectiveTo investigate the expression level of cytochrome b561 (CYB561) in endometrial carcinoma tissues and analyze its relationship with clinicopathological characteristics and patient prognosis.

methodsBioinformatic analysis was performed to assess CYB561 mRNA expression and its correlation with prognosis in endometrial cancer. Immunohistochemical staining was used to detect CYB561 protein expression in 195 endometrial carcinoma tissues and 40 adjacent normal endometrial tissues. The associations between CYB561 expression and clinicopathological parameters, as well as its impact on overall survival (OS) and disease-free survival (DFS), were analyzed.

resultsCYB561 expression was significantly higher in endometrial carcinoma tissues compared to adjacent normal tissues (P < 0.001). Low CYB561 expression was significantly associated with advanced FIGO stage (P < 0.05). Moreover, patients with low CYB561 expression exhibited significantly poorer overall survival (OS) and disease-free survival (DFS) (log-rank P < 0.001 for both).

conclusionCYB561 is up-regulated in endometrial carcinoma, and its high expression is associated with a more favorable prognosis, suggesting its potential role as a prognostic biomarker for endometrial cancer.

Indexed as

Biomarkers, TumorEndometrial NeoplasmsAdultAgedDisease-Free SurvivalFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryMiddle AgedNeoplasm StagingPrognosisRNA, MessengerBiomarkers, TumorRNA, MessengerBiomarkerCytochrome b561Endometrial carcinomaImmunohistochemistryPrognosis

Identifiers

PMID42082769
PMCPMC13139544

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.