ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Psychological distress and quality of life in patients with indolent non-Hodgkin lymphoma.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveIndolent non-Hodgkin lymphoma (iNHL) is a chronic, incurable lymphoid malignancy with a slow course. In absence of symptoms, a 'watchful waiting' approach is often chosen. The emotional burden of uncertainty and monitoring may affect patients' psychological well-being. This study investigates the extent of psychological distress in iNHL patients and its relationship with sociodemographics, clinical characteristics, and quality of life.
methodsA cross-sectional study was conducted among adults with histologically confirmed indolent B-cell or T-cell NHL, recruited via a regional Dutch hospital and the online patient platform CMyLife. Data were collected through self-administered online questionnaires, including sociodemographics, clinical characteristics, psychological distress (HADS) and quality of life (EORTC QLQ-C30/LG-NHL).
resultsA total of 352 iNHL patients completed the questionnaires (response rate: 37.5%). The mean age was 69 years, 58.5% were male and psychological distress (HADS ≥ 13) was observed in 30.7% of participants. Distressed patients were more often female, less educated, more frequently in the period of watchful waiting, and had more medical comorbidities (p < .01). They reported significantly lower health-related quality of life (HRQoL) (mean 51.2 vs. 77.6) and a higher symptom burden. Psychological distress was strongly correlated with lower HRQoL (r = -.63). In hierarchical regression analysis, psychological distress was the strongest predictor of lower HRQoL (β = -0.605, p < .001).
conclusionsApproximately one-third of iNHL patients experience psychological distress, significantly associated with female gender, a lower education level, a watchful waiting approach, medical comorbidities, and a lower HRQoL. This underscores the importance of attention for these factors during consultations.
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