Evidence map›Paper›PMID 42082722›Full record

ArticleNPJ precision oncology2026

Liquid-liquid phase separation of CBX2 regulates lipid raft-mediated extracellular vesicle biogenesis to facilitate ovarian carcinoma metastasis.

Qiulei Wu, Xiaohan Xu, Xiaoli Liu, Wenhan Li, Guoqing Li, Lanqing Gong, Lin Huang, Pan Liu, Feiquan Ying, Tong Liu and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Qiulei Wu *Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiaohan Xu *Department of Gynecology, Qingdao Municipal Hospital, Qingdao, China.
Xiaoli Liu *Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wenhan LiDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Guoqing LiDepartment of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lanqing GongDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lin HuangDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Pan LiuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Feiquan YingDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tong LiuDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuanyuan LiDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wenting ZhangDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xinyi WuDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yisu GaoDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Si SunDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zehua WangDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jing CaiDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jianfeng GuoDepartment of Gynecology, Affiliated Longhua Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China. guojf624@foxmail.com.
Lin LiuDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. linliu_whxh@hust.edu.cn.
Ping YangDepartment of Obstetrics and Gynecology, Xinjiang Production and Construction Corps Hospital, Urumqi, China. yangping@shzu.edu.cn.

Funding

the National Natural Science Foundation of China 82303128the National Natural Science Foundation of China 82303514the National Natural Science Foundation of China 82360541the National Natural Science Foundation of China 82403619Tianshan Ying Talents Leading Talents in Science and Technology Innovation-High-level Leading Talents 2022TSYCLJ0055Xinjiang Production and Construction Corps Clinical Research Center for Gynecological and Obstetrical Diseases CZ001230
6 · The paper itself

Abstract

Extracellular vesicles (EVs) play a vital role in ovarian carcinoma (OvCa) metastasis, yet the mechanisms regulating EV biogenesis remain unclear. Here, we identify CBX2 as a key driver of omental metastasis, with elevated expression in metastatic lesions and association with poor prognosis. CBX2 promotes tumor cell migration, invasion, and metastasis by enhancing EV secretion and pro-metastatic cargo loading through remodeling lipid rafts, cholesterol-rich membrane microdomains essential for EV formation. Deletion of the intrinsically disordered region abolishes lipid raft remodeling and multivesicular body redistribution, indicating dependence on liquid-liquid phase separation (LLPS). CBX2 also transcriptionally upregulates FLOT1 in an LLPS-dependent manner. Disruption of lipid rafts or inhibition of CBX2 phase separation markedly reduces EV production and metastatic potential. These findings reveal an LLPS-dependent mechanism linking CBX2 to lipid raft-mediated EV biogenesis and OvCa metastasis.

Identifiers

PMID42082722
PMCPMC13342620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.