ArticleCommunications biology2026
FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Deep-Pose-Tracker: an automated behavioural analysis framework for Caenorhabditis elegans.Scientific reports · 2026Article
- Neuromodulation of swarming behavior inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- FLP-15 modulates the amplitude of body-bends during locomotion inOpen biology · 2025Article
- Neuromodulation of Swarming Behavior inbioRxiv : the preprint server for biology · 2025Article
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Abstract
The transition from well-fed to food-deprived conditions in C. elegans triggers a stereotypic exploration behaviour characterised by a temporal decrease in reorientation frequency. In this study we conduct a screen of neuropeptide mutants and identify several candidates involved in modulating this behaviour. Among these, the neuropeptide FLP-15 emerges as a key regulator. Our observations reveal that FLP-15 regulates the frequency of reversals during foraging through the I2 pharyngeal neuron via the G protein-coupled receptor NPR-3. Mutants lacking either flp-15, npr-3 or both display a significant defect in reversal frequency which does not decline temporally unlike in wild-type animals. This study also describes the expression pattern of NPR-3 in a subset of head neurons, predominantly comprising of dopaminergic neurons. Finally, flp-15 expression studies and exogenous dopamine supplementation assays reveal that FLP-15 may regulate exploratory search by modulating dopamine transmission, highlighting a novel neuropeptide-dopamine interaction involved in the control of foraging behaviours.
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