ArticleEuropean journal of pediatrics2026
Contrasting MRI patterns in early infant human parechovirus CNS infection: a brief report.
Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human parechovirus (HPeV), particularly genotype A3, is a recognized cause of sepsis-like illness and central nervous system (CNS) infection in neonates and young infants. Brain magnetic resonance imaging (MRI) plays a key role in identifying CNS involvement, although neuroradiological findings may be heterogeneous. We report two infants with PCR-confirmed HPeV CNS infection presenting at 10 and 40 days of life, respectively, with contrasting MRI patterns. The first neonate showed the typical phenotype of bilateral fronto-parietal and periventricular white matter diffusion restriction despite minimal cerebrospinal fluid (CSF) pleocytosis. The second infant demonstrated isolated diffuse leptomeningeal enhancement without parenchymal lesions. Both patients experienced rapid clinical recovery and remained seizure-free; neurodevelopment was normal at follow-up in the case with white matter involvement. These observations highlight the spectrum of MRI findings in early infant HPeV CNS infection and reinforce that normal or near-normal CSF parameters do not exclude significant CNS involvement. Early MRI, combined with molecular testing, may improve diagnostic accuracy and inform follow-up strategies.
conclusionThese observations highlight the spectrum of MRI findings in early infant HPeV CNS infection and reinforce that normal or near-normal CSF parameters do not exclude significant CNS involvement. Early MRI, combined with molecular testing, may improve diagnostic accuracy and inform follow up strategies. WHAT IS KNOWN: • Human parechovirus (HPeV) CNS infection in young infants is commonly associated with white-matter diffusion abnormalities on MRI and minimal or absent CSF pleocytosis. • MRI is a key diagnostic tool in identifying CNS involvement, although neuroradiological findings may be heterogeneous. WHAT IS NEW: • This report describes two infants with HPeV CNS infection showing contrasting MRI patterns, including isolated leptomeningeal enhancement without parenchymal lesions. • These findings broaden the recognized neuroradiological spectrum of HPeV infection and highlight the diagnostic value of MRI even in clinically mild cases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.