Quantification of gastric cancer biomarkers in the urine matrix by high internal phase emulsion polymer-based µsolid-phase extraction followed by HPLC-MS/MS.

Francesca Merlo, Matteo Invernizzi, Sofia Salerno, Enrica Calleri, Antonella Profumo, Andrea Speltini

Abstract read

In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Integrated Fe(III)-driven liquid-phase microextraction-spectrophotometry for selective and high-throughput detection of ethyl maltol in complex food samples.Analytical and bioanalytical chemistry · 2026
Article

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Francesca MerloDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.

Matteo InvernizziDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.

Sofia SalernoDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.

Enrica CalleriDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.

Antonella ProfumoDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.

Andrea SpeltiniDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy. andrea.speltini@unipv.it.ORCID http://orcid.org/0000-0002-6924-7170

Funding

Ministero dell'Università e della Ricerca Dipartimenti di Eccellenza 2023-2027

6 · The paper itself

Abstract

This paper reports on the development of an analytical method for the simultaneous determination of 4-methyl phenol, 4-hydroxybenzoic acid and five bile acids, namely cholic acid, glycochenodeoxycholic acid, chenodeoxycholic acid, deoxycholic acid, and hyodeoxycholic acid (logP 1.6-4.9) in urine, exploring porous acrylic polymers as unconventional solid-phase extraction sorbents before HPLC-MS/MS analysis. These materials, obtained by polymerization of high internal phase emulsions with different composition, were used in a miniaturized setting (µSPE), preliminarily in synthetic urine samples enriched with 200 ng mL

Indexed as

BioanalysisBiomarkersClean-upSample preparationSolid-phase extractionSorptive phase

Identifiers

PMID42082668

DOI10.1039/D3GC02347H

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.