Articlenpj biomedical innovations2026
DNA cross-over motifs-based, programmable supramolecular hydrogels for the mechanoregulatory effects of cellular behaviour and cytoskeleton reorganization.
Article in npj biomedical innovations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Design and Characterization of DX-Tile DNA Nanostar-Based Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The development of mechanically tunable hydrogels that replicate the dynamic mechanoelastic properties of native extracellular matrices (ECMs) is essential for advancing 3D tissue engineering. DNA, with its precise, programmable architecture and exceptional control at the nanometre scale, offers a valuable platform for designing ECM-mimicking scaffolds. This study presents stiffness-tuneable DNA supramolecular hydrogels with different branching architectures for programming cellular and organellar states. Utilizing precise DNA motifs-including DX (Double Crossovers), PX (Paranemic Crossovers), and Tensegrity architectures-we engineer hydrogels with widely adjustable mechanical properties (50-185 kPa) without chemical additives or enzymatic crosslinking. These hydrogels exhibit excellent strain-bearing and load-bearing capacity, making them suitable for biomedical applications. Additionally, these DNA hydrogels influence cellular behaviour in retinal pigment epithelial (RPE1) cells by enhancing cellular adhesion, encouraging elongation (a 3-8-fold increase in area compared to control), and improving viability (dependent on concentration, 1-8-fold increase vs. control), while also maintaining organellar homeostasis, including mitochondrial fragmentation and ER stress reduction. This work presents a framework for automating the production of stiffness-tunable DNA hydrogel scaffolds, aligning with the mechanical needs of various cells and tissues, thereby advancing personalized, high-throughput tissue engineering platforms.
Identifiers
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Registered trials
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