Evidence map›Paper›PMID 42082525›Full record

ArticleNature communications2026

5'tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes.

Cristina Cosentino, Rémy Klein, Véronique Menoud, Claudiane Guay, Elena Aiello, Stefano Auddino, Gianfranco Di Giuseppe, Gea Ciccarelli, Alessandra Galli, Francesco Alabiso and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Cristina CosentinoDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland. cristina.cosentino@unil.ch.ORCID http://orcid.org/0000-0002-2876-3953
Rémy Klein *Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.
Véronique Menoud *Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.
Claudiane GuayDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6478-8744
Elena AielloDipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy.ORCID http://orcid.org/0000-0002-2054-4369
Stefano AuddinoDipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy.
Gianfranco Di GiuseppeDepartment of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0003-4506-5193
Gea CiccarelliDepartment of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Alessandra GalliDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.
Francesco AlabisoDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-6101-062X
Eleonora ManganoInstitute for Biomedical Technologies, National Research Council, Milan, Italy.
Flora BrozziDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.
Karim BouzakriUMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Stefania D'AdamoDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-2209-9158
Silvia CetrulloDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Giuseppe QueroDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Andrea MariInstitute of Neuroscience, National Research Council, Padua, Italy.ORCID http://orcid.org/0000-0002-1436-5591
Sergio AlfieriDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Andrea GiaccariDepartment of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-7462-7792
Teresa MezzaDepartment of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Francesco DottaDipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy.ORCID http://orcid.org/0000-0003-4947-7478
Guido SebastianiDipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy.ORCID http://orcid.org/0000-0003-4374-8564
Romano RegazziDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-9773-2915

Funding

EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 101029421Ministero della Salute (Ministry of Health, Italy) GR-2018-12365577Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PNRR-MCNT2-2023-12378096Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PNRR-PRIN2022 No. P2022EB5B8Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PNRR-PRIN2022 Prot. P2022445ESMinistero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PRIN2022 No.2022FRBXHYMinistero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PRIN Prot. 2022TJWNLLSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_219252Université de Lausanne (University of Lausanne) FBM-Transition Grant 2023
6 · The paper itself

Abstract

Obesity and diabetes impose chronic stress on pancreatic β-cells, while reprogramming of islet-resident macrophages (iMACs) accelerates dysfunction. Here, we identify transfer RNA-derived fragments (tRFs) as previously unrecognized mediators of islet remodeling under metabolic stress. 5'tRF

Indexed as

Diabetes Mellitus, Type 2Insulin-Secreting CellsIslets of LangerhansMacrophage ActivationMacrophagesRNA, TransferAnimalsCoculture TechniquesHomeostasisHumansInsulinInsulin SecretionMaleMiceMice, Inbred C57BLOxidative StressInsulinRNA, Transfer

Identifiers

PMID42082525
PMCPMC13346763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.