Evidence map›Paper›PMID 42082491›Full record

Trial reportNature communications2026

NH600001, an etomidate analogue, provides gastrointestinal endoscopy sedation/anesthesia and reduces adrenocortical depression: two randomized controlled trials.

Yingyong Zhou, Kaiming Duan, Shichao Luo, Shengping Liu, Qiongcan Li, Songhua Liu, Huajing Guo, Haitao Jiang, Guyan Wang, Huijun Wang and 28 more

Abstract readClinical Trial, Phase IIClinical Trial, Phase IIIMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Yingyong Zhou *Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China.ORCID http://orcid.org/0000-0003-0243-354X
Kaiming Duan *Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China.
Shichao LuoDepartment of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China.
Shengping LiuDepartment of Endocrinology, The Third Xiangya Hospital of Central South University, Changsha, China.
Qiongcan LiDepartment of Anesthesiology, Changsha Central Hospital, Changsha, China.
Songhua LiuDepartment of Anesthesiology, Changsha Central Hospital, Changsha, China.
Huajing GuoDepartment of Anesthesiology, The First People's Hospital of Changde, Changde, China.
Haitao JiangDepartment of Anesthesiology, Yueyang People's Hospital, Yueyang, China.
Guyan WangDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Huijun WangDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Zhiping WangDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Xiaobao ZhangDepartment of Anesthesiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang, Lianyungang, China.
Canlin SunDepartment of Anesthesiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Qiang WangDepartment of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wei GaoDepartment of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wangning ShangguanDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhongyuan XiaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Ailin LuoDepartment of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chun ChenDepartment of Anesthesiology, Yichang Central People's Hospital, Yichang, China.
Mengchang YangDepartment of Anesthesiology, Sichuan Academy of Medical Sciences-Sichuan Provincial People's Hospital (SAMSPH), Chengdu, China.
Wenjie SuDepartment of Anesthesiology, Sichuan Academy of Medical Sciences-Sichuan Provincial People's Hospital (SAMSPH), Chengdu, China.
Xiaohua ZouDepartment of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Yalan LiDepartment of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Hao WangDepartment of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID http://orcid.org/0000-0003-2169-1712
Yanjuan HuangDepartment of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning Second People's Hospital, Nanning, Guangxi, China.ORCID http://orcid.org/0000-0003-0744-9727
Ruping DaiDepartment of Anesthesiology, The Second Xiangya Hospital of Central South University, Changsha, China.ORCID http://orcid.org/0000-0002-1027-6698
Qian ZhaoDepartment of Anesthesiology, The Fourth Hospital of Changsha, Changsha, China.
Shuan JingDepartment of Anesthesiology, Jinan Central Hospital, Jinan, China.
Linzhong ZhangDepartment of Anesthesiology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Wenjun YanDepartment of Anesthesiology, Gansu Provincial Hospital, Lanzhou, China.
Xingang QinDepartment of Anesthesiology, The Fifth Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.
Juan WangDepartment of Anesthesiology, Huaibei Miner General Hospital, Huaibei, China.
Jingli ChenDepartment of Anesthesiology, Wuhan Central Hospital, Wuhan, China.
Jun CaoDepartment of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Minsheng ZhangDepartment of Anesthesiology, Jiangxi Provincial People's Hospital, Nanchang, China.
Shuchun YuDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Wen OuyangDepartment of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China. ouyangwen139@126.com.
Saiying WangDepartment of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China. wsyxy3yy@csu.edu.cn.ORCID http://orcid.org/0000-0003-0083-5764

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the efficacy and safety of NH600001, a novel etomidate derivative, in gastrointestinal endoscopy, as well as its impact on adrenocortical function, two multicenter, double-blind, randomized, controlled clinical trials(NH600001-21 [Phase II trial] and NH600001-31 [Phase III trial]) were conducted in China. In NH600001-21, 160 gastroscopy subjects were randomized 1:1:1:1 to receive NH600001 (0.20, 0.25, or 0.30 mg/kg) and etomidate (0.30 mg/kg). In NH600001-31, 344 gastroscopy or colonoscopy subjects were randomized in a 1:1 ratio to receive NH600001 (0.25 mg/kg) and etomidate (0.30 mg/kg). The primary efficacy outcome was the rate of endoscopic success. Additionally, Safety and effects on adrenocortical function were also assessed. In NH600001-21, the 0.25 mg/kg NH600001 showed non-inferiority to etomidate based on the prespecified non-inferiority margin of -8% (Rate Difference [95% confidence interval], 5.0[-4.49 to 14.49]), whereas the 0.20 mg/kg and 0.30 mg/kg NH600001 did not meet statistical non-inferiority criteria (0[-11.54 to 11.54]; 0[-11.54 to 11.54]). The area under curve (AUC) of plasma cortisol change values within 0-4 h (∆Cortisol AUC

Indexed as

Adrenal CortexEndoscopy, GastrointestinalEtomidateHypnotics and SedativesAdultAnesthesiaChinaDouble-Blind MethodFemaleHumansMaleEtomidateHypnotics and Sedatives

Identifiers

PMID42082491
PMCPMC13342565

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.