ArticleArchives of disease in childhood2026
Measuring transition success from paediatric to adult epilepsy services and its association with seizure outcomes: a UK retrospective cohort study.
Article in Archives of disease in childhood, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo develop a working definition of successful transition from paediatric to adult epilepsy services, assess transition success, identify predictors and determine whether success is associated with improved seizure outcomes in early adulthood.
designRetrospective cohort study.
settingPaediatric and adult epilepsy services in London, UK.
participantsPatients aged 20-24 with epilepsy in the paediatric service database (2009-2023) who transitioned to adult care. DEMOGRAPHICS: Date of birth, sex, ethnicity. EXPOSURES: Age at first documented paediatric epilepsy clinical appointment (this is not age of epilepsy onset) and number of epilepsy-related comorbidities at age 17. TRANSITION MEASURE: Success was defined by four criteria: developmentally appropriate initiation, comprehensive preparation using National Institute for Health and Care Excellence guidance, attendance at joint paediatric/adult transition clinic and adult follow-up within 6 months of transition clinic.
main outcome measureChange in seizure frequency between ages 17 and 20.
resultsOf 59 eligible patients, 72.9% (43/59) achieved successful transition. Criteria were well-met: initiation (91.5%), preparation (91.5%), joint clinic (79.7%) and follow-up (88.1%). Successful transition increased the odds of seizure improvement/remaining seizure-free (adjusted OR 4.28, 95% CI 1.07 to 17.19) after adjusting for: age at first paediatric epilepsy clinical appointment, sex, ethnicity and comorbidities. Males had higher odds of seizure improvement/remaining seizure free than females (adjusted OR 4.29, 95% CI 1.26 to 14.67).No significant association was seen with ethnicity or age at first appointment.
conclusionsA novel transition success tool was developed. Larger, multicentre studies are needed to validate this tool and confirm associations with long-term outcomes.
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