Evidence map›Paper›PMID 42082081›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026

Tensor-based integration of time-series measurements reveals relationships between underlying disease, early injury, and T cell polarization in liver transplantation.

Jackson L Chin, Zhixin Cyrillus Tan, Rebecca A Sosa, Ying Zheng, David W Gjertson, Alexander Hoffmann, Fady M Kaldas, Yuan Zhai, Jerzy W Kupiec-Weglinski, Elaine F Reed and 1 more

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Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jackson L ChinDepartment of Bioengineering, UCLA, Los Angeles, California, USA.
Zhixin Cyrillus TanBioinformatics Interdepartmental Program, UCLA, Los Angeles, California, USA.
Rebecca A SosaDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, California, USA.
Ying ZhengDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, California, USA.
David W GjertsonDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, California, USA.
Alexander HoffmannBioinformatics Interdepartmental Program, UCLA, Los Angeles, California, USA; Department of Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, California, USA; Institute for Quantitative and Computational Biosciences, UCLA, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA; The Dumont-UCLA Transplantation Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Fady M KaldasThe Dumont-UCLA Transplantation Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Yuan ZhaiDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA; The Dumont-UCLA Transplantation Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Jerzy W Kupiec-WeglinskiDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, California, USA; The Dumont-UCLA Transplantation Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, California, USA.
Aaron S MeyerDepartment of Bioengineering, UCLA, Los Angeles, California, USA; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, California, USA; Institute for Quantitative and Computational Biosciences, UCLA, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, California, USA. Electronic address: ameyer@asmlab.org.

Funding

Regulation of Innate Immune Responses by Alloimmunity in Liver Ischemia-Reperfusion InjuryP01AI120944 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jerzy W Kupiec-Weglinski · 2017 to 2026
$20.0M
Systems Epigenomics of Persistent Bloodstream InfectionU19AI172713 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Michael R Yeaman · 2023 to 2026
$11.6M
NIAID NIH HHS P01 AI120944NIAID NIH HHS U19 AI172713
6 · The paper itself

Abstract

A lack of integrative analyses in liver transplantation (LT) limits understanding of relationships between immunologic signatures, time, and recipient/donor health factors in LT. In this exploratory study, we collected cytokine and liver function test measurements from LT donors and recipients at multiple pre- and postoperative timepoints. We developed a tensor-based factorization method to reduce these measurements to 4 components that manifested across cytokines, liver function tests, and time. These components associated preoperative immune signatures with immune signatures up to a month postoperation. Integration of allograft survival into this factorization reduced these 4 components to 2 associated with 5-year allograft survival. These signatures suggested that pronounced cluster of differentiation 4 (CD4+) polarization was associated with impaired growth factor expression and increased allograft loss risk. Donor and recipient age modulated this CD4+ polarization. These findings provide insights into the immunologic signatures of LT, identifying potential therapeutic avenues for future validation.

Indexed as

Graft RejectionGraft SurvivalLiver TransplantationT-LymphocytesAdultCytokinesFemaleFollow-Up StudiesHumansLiver Function TestsMaleMiddle AgedPrognosisRisk FactorsTissue DonorsCytokinesallograft survivalliver function testsliver transplantationlongitudinal analysissystems immunologytensor factorizationTh1/Th2 response

Identifiers

PMID42082081
PMCPMC13198774

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.