Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Yang YangDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0002-0942-1800
Constance L AtkinsDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.
Yuanyuan FanDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0003-4677-4880
Lidan HouDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.
Jie ZhaoDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.
Junda GaoDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0009-0004-8857-7580
Yankai WenDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0002-8144-1515
Nicolas F MorenoDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0001-8661-676X
Xiangsheng HuangDepartment of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.
Faraz BishehsariDepartment of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.
Agnieszka K CzopikDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.
Sean P ColganMucosal Inflammation Program, Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0003-0431-8887
Tugrul PurnakDepartment of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.ORCID 0000-0003-2665-4785
Keith C SummaDivision of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0001-9541-8458
Yingzi CongDivision of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0003-4167-7395
Elizabeth A JacobsenDivision of Allergy, Asthma and Clinical Immunology, Mayo Clinic, Scottsdale, AZ 85259.ORCID 0000-0003-2956-753X
Cynthia JuDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030.
Funding
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI145108HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK121330HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA030735
6 · The paper itself
Abstract
Inflammatory bowel disease (IBD) is driven by a breakdown in immune regulation and epithelial barrier function, yet the contribution of eosinophils to this process has remained poorly defined and controversial. While eosinophils infiltrate the intestinal mucosa during both flares and remission, their role in shaping disease outcomes is unclear. Our RNA-seq analyses of colonic eosinophils isolated from dextran sulfate sodium (DSS)-treated mice revealed a significant upregulation of cyclooxygenase (COX)-2 (gene name,
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Eosinophil-derived COX-2 protects against experimental colitis through the PGE · full record | OpenQuestion