Evidence map›Paper›PMID 42081617›Full record

ArticleChemistry & biodiversity2026

Talaroindiones A-C, New Polyketides Characterized From the Cold-Seep-Derived Talaromyces indigoticus CS-469.

Ruo-Xi Deng, Xiao-Ming Li, Bin-Gui Wang, Ling-Hong Meng

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ruo-Xi DengLaboratory of Experimental Marine Biology, Shandong Province Key Laboratory of Marine Biodiversity and Bio-Resource Sustainable Utilization, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Xiao-Ming LiLaboratory of Experimental Marine Biology, Shandong Province Key Laboratory of Marine Biodiversity and Bio-Resource Sustainable Utilization, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.ORCID https://orcid.org/0000-0001-5838-2265
Bin-Gui WangLaboratory of Experimental Marine Biology, Shandong Province Key Laboratory of Marine Biodiversity and Bio-Resource Sustainable Utilization, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Ling-Hong MengLaboratory of Experimental Marine Biology, Shandong Province Key Laboratory of Marine Biodiversity and Bio-Resource Sustainable Utilization, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.ORCID https://orcid.org/0000-0001-6884-0346

Funding

National Key Research and Development Program of China 2024YFC2815900Special Project of Benefiting People with Science and Technology of Qingdao 26-1-5-smjk-4-nsh
6 · The paper itself

Abstract

Three novel polyketides, talaroindiones A-C (1-3), along with two known diphenyl ether derivatives (4 and 5) were isolated from the rice culture medium extract of the marine-derived fungus Talaromyces indigoticus CS-469. The structures of 1-3 were determined by comprehensive spectroscopic analysis and confirmed by single-crystal x-ray diffraction. Their absolute configurations were assigned using TDDFT-ECD calculations, while those of 4 and 5 were established by comparison of their experimental optical rotations with literature values. All compounds were evaluated for their antibacterial activity. Compound 4 exhibited broad-spectrum inhibitory activities against six bacterial strains, showing particularly potent activity against Vibrio harveyi and Vibrio parahaemolyticus with MIC values of 2 µg/mL.

Indexed as

Anti-Bacterial AgentsPolyketidesTalaromycesCrystallography, X-RayMicrobial Sensitivity TestsMolecular ConformationMolecular StructureVibrioVibrio parahaemolyticusAnti-Bacterial AgentsPolyketidesantibacterial activitymarine funguspolyketidessecondary metabolitestalaromyces indigoticus

Identifiers

PMID42081617
PMCPMC13381011

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.