Evidence map›Paper›PMID 42081594›Full record

ArticleChemistry & biodiversity2026

Therapeutic Potential of Origanum majorana L. Essential Oil in Diabetes Mellitus: Insights From GC-MS Characterization, In Vivo Hypoglycaemic Studies, and In Silico Analyses.

Mahmoud Houas, Mohammed Larbi Benamor, Elhafnaoui Lanez, Yahia Bekkar, Lotfi Bourougaa, Ouafa Boudebia, Rania Bouraoui, Aicha Adaika, Nafila Zouaghi, Salah Neghmouche Nacer and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mahmoud HouasLaboratory For the Study and Development of Water Treatment and Purification Techniques and Environmental Management, Higher Normal School of Kouba, Kouba, Algeria.
Mohammed Larbi BenamorFaculty of Exact Sciences, Department of Chemistry, VTRS Laboratory, University of El Oued, El Oued, Algeria.
Elhafnaoui LanezFaculty of Exact Sciences, Department of Chemistry, VTRS Laboratory, University of El Oued, El Oued, Algeria.ORCID https://orcid.org/0000-0002-6543-2547
Yahia BekkarFaculty of Exact Sciences, Department of Chemistry, VTRS Laboratory, University of El Oued, El Oued, Algeria.ORCID https://orcid.org/0000-0001-5816-2043
Lotfi BourougaaFaculty of Exact and Natural Sciences, Department of Matter Sciences, LMCE Laboratory, University of Biskra, Biskra, Algeria.ORCID https://orcid.org/0009-0005-4235-6077
Ouafa BoudebiaFaculty of Exact Sciences, Department of Chemistry, VTRS Laboratory, University of El Oued, El Oued, Algeria.
Rania BouraouiFaculty of Material Sciences, Department of Chemistry, LCCE Laboratory, University of Batna-1, Batna, Algeria.
Aicha AdaikaFaculty of Exact Sciences, Department of Chemistry, VTRS Laboratory, University of El Oued, El Oued, Algeria.
Nafila ZouaghiLaboratory For the Study and Development of Water Treatment and Purification Techniques and Environmental Management, Higher Normal School of Kouba, Kouba, Algeria.
Salah Neghmouche NacerDepartment of Chemistry, Faculty of Exact Sciences, University of El Oued, El Oued, Algeria.
Lazhar BechkiVPRS Laboratory, Department of Chemistry, Faculty of Mathematics and Material Sciences, Kasdi Merbah University, Ouargla, Algeria.ORCID https://orcid.org/0000-0002-2242-8310
Touhami LanezFaculty of Exact Sciences, Department of Chemistry, VTRS Laboratory, University of El Oued, El Oued, Algeria.
Stefania GarzoliDepartment of Chemistry and Technologies of Drug, Sapienza University, Rome, Italy.ORCID https://orcid.org/0000-0001-8535-0533

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a widespread metabolic disorder characterized by impaired glucose regulation. This study investigated the chemical composition and antidiabetic potential of Origanum majorana essential oil (EO) using integrated in vitro, in vivo, and computational approaches. GC-MS analysis identified 42 constituents representing 96.28% of the oil, with trans-thujone (33.30%), santolina triene (16.42%), and cis-verbenyl acetate (15.05%) as the dominant components. In vitro assays revealed strong inhibitory activity against carbohydrate-hydrolyzing enzymes, with IC

Indexed as

Diabetes Mellitus, ExperimentalHypoglycemic AgentsOils, VolatileOriganumalpha-Amylasesalpha-GlucosidasesAnimalsBlood GlucoseGas Chromatography-Mass SpectrometryMaleMolecular Docking SimulationRatsRats, Wistaralpha-Amylasesalpha-GlucosidasesBlood GlucoseHypoglycemic AgentsOils, VolatileADMET analysisDFT analysisGC‐MS analysisMM‐PBSAmolecular dockingmolecular dynamics simulations

Identifiers

PMID42081594
PMCPMC13138695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.