Evidence map›Paper›PMID 42081392›Full record

ArticleFetal diagnosis and therapy2026

Fetal Pulmonary Vascular Assessment and Its Association with Postnatal Ductus Arteriosus Flow in Infants with a Congenital Diaphragmatic Hernia.

Katinka Weller, Alex J Eggink, Laurens P Koopman, Suzan C M Cochius-Den Otter, Eric A P Steegers, Irwin K M Reiss, Philip L J DeKoninck, Nina C J Peters

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Article in Fetal diagnosis and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katinka WellerDivision of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands, k.weller@erasmusmc.nl.
Alex J EgginkDivision of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Laurens P KoopmanDepartment of Pediatric Cardiology, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Suzan C M Cochius-Den OtterDivision of Pediatric Intensive Care, Department of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Eric A P SteegersDivision of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Irwin K M ReissDivision of Pediatric Intensive Care, Department of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Philip L J DeKoninckDivision of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Nina C J PetersDivision of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of the study was to evaluate the association between fetal right pulmonary artery (RPA) parameters and postnatal ductus arteriosus velocity-time integral (DA VTI) ratios in neonates with mild or moderate left-sided congenital diaphragmatic hernia (L-CDH), and their predictive value for clinical outcomes.

methodsIn this prospective cohort study, 49 fetuses with mild or moderate L-CDH were evaluated between 2012 and 2018. RPA diameter and pulsatility index (PI) were measured at 19-24, 25-29, and 30-32 weeks of gestational age (GA). Postnatal DA VTI ratios were assessed at initial echocardiography after birth. An abnormal DA VTI ratio (<1.0) served as the primary outcome. Associations between prenatal RPA parameters, postnatal DA VTI ratios, and neonatal outcomes were analyzed.

resultsA smaller RPA diameter at 30-32 weeks of GA was associated with an abnormal DA VTI ratio (p = 0.015). An RPA diameter cutoff of 2.71 mm yielded 60% sensitivity and 84% specificity (area under the curve = 0.74, p = 0.005). Neonates with abnormal DA VTI ratios had higher rates of pulmonary hypertension treatment, need for extracorporeal membrane oxygenation, and lower survival. No associations were found between prenatal RPA PI and DA VTI ratios.

conclusionIn mild and moderate L-CDH, smaller RPA diameters in third-trimester associate with abnormal DA VTI ratio on initial echocardiography after birth.

Indexed as

Congenital diaphragmatic herniaDuctus arteriosusLung vasculaturePrenatal ultrasound

Identifiers

PMID42081392
PMCPMC13331466

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.