Evidence map›Paper›PMID 42081236›Full record

ArticleJAMA neurology2026

Precision Antisense Oligonucleotide Therapy Amenability for Infantile Genetic Epilepsies.

Emma Sherrill, David Cheerie, Cara J Beck, Ella F Whittle, Yasin Shafi, Natalie J Chandler, John Christodoulou, Jerusalem Daniel, Jane Hassell, Maria Lachgar-Ruiz and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. From N-of-1 therapy to health-system implementation.Nature reviews. Drug discovery · 2026
    Article
  2. Genetic Diagnosis in Epilepsy: Implications for Clinical Management.Current neurology and neuroscience reports · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Emma SherrillDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
David CheerieProgram in Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada.
Cara J BeckMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Ella F WhittleGenetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, United Kingdom.
Yasin ShafiGenetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, United Kingdom.
Natalie J ChandlerNorth Thames Genomic Laboratory Hub, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.
John ChristodoulouMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Jerusalem DanielDepartment of Genetics, Evolution and Environment (GEE), University College London, London, United Kingdom.
Jane HassellDepartment of Neurology, Great Ormond Street Hospital, London, United Kingdom.
Maria Lachgar-RuizNorth Thames Genomic Laboratory Hub, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.
Sarah MulhernMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Elizabeth ScotchmanNorth Thames Genomic Laboratory Hub, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.
Jashanpreet SidhuProgram in Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada.
Celine Florentia TedjaDivision of Biosciences, University College London, London, United Kingdom.
Lyn S ChittyGenetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, United Kingdom.
J Helen CrossDepartment of Neurology, Great Ormond Street Hospital, London, United Kingdom.
Ingrid E SchefferMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Haiyan ZhouGenetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, United Kingdom.
Timothy W YuDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
Vann ChauDivision of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada.
Sarah E M StephensonMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Annapurna PoduriF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts.
Katherine B HowellMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Amy McTagueDepartment of Neurology, Great Ormond Street Hospital, London, United Kingdom.
Gregory CostainProgram in Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada.
Alissa M D'GamaDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Gene-STEPS Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42081236
PMCPMC13140085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.