Evidence map›Paper›PMID 42081182›Full record

ArticleCurrent medical science2026

Integrated DNA Repair Capacity and NER Gene Expression for Improving Risk Prediction in Head and Neck Squamous Cell Carcinoma.

Ling Zhang, Yi-Qian Liang, Xiao-Rong Niu, Fang Sui, Yan-Xia Bai, Shao-Qiang Zhang, Hai-Yan Cai, Xiao-Tong Zhang, Peng Han

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Article in Current medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ling Zhang *Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Yi-Qian Liang *Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Xiao-Rong Niu *Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Fang SuiDepartment of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Yan-Xia BaiDepartment of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Shao-Qiang ZhangDepartment of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Hai-Yan CaiDepartment of Neurology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, 750002, China. haiyan616@163.com.
Xiao-Tong ZhangDepartment of Otorhinolaryngology-Head and Neck Surgery, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710004, China. tracylizhang@189.cn.
Peng HanDepartment of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China. penghanent@hotmail.com.ORCID http://orcid.org/0000-0003-4115-4439

Funding

Natural Science Basic Research Program of Shaanxi Province 2023-JC-YB-791Natural Science Foundation of China 81902322Natural Science Foundation of China 82571316
6 · The paper itself

Abstract

objectiveDNA repair plays a critical role in the development of smoking-related cancers. We hypothesized that DNA repair capacity (DRC) and nucleotide excision repair (NER) mRNA expression are associated with increased head and neck squamous cell carcinoma (HNSCC) risk in the Chinese population.

methodsWe conducted a case-control study including 349 patients with HNSCC and 316 cancer-free controls. DRC and NER mRNA expression levels were measured in lymphoblastoid cells exposed to benzo[a]pyrene diol epoxide (BPDE). Correlations between DRC and NER mRNA expression were analyzed, and their associations with HNSCC risk were evaluated.

resultsThe mean DRC was significantly lower in patients with HNSCC (9.72% ± 2.25%) than in healthy controls (10.81% ± 2.63%, P < 0.001). Compared with individuals with higher DRCs, those with lower DRCs had a significantly greater risk of HNSCC (odds ratio [OR] = 2.23, 95% confidence interval [CI] = 1.60-3.10, P < 0.001; P

conclusionsSuboptimal DRC and reduced expression of key NER genes, particularly XPA and XPB, are associated with increased HNSCC risk. Integrating these two NER biomarkers may provide a novel and improved model for HNSCC risk assessment.

Indexed as

DNA RepairExcision RepairHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and Neck7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideAgedCase-Control StudiesFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedRisk FactorsRNA, Messenger7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideRNA, MessengerBiomarkersCancer susceptibilityCase-control studiesDNA repairHead and neck neoplasmsNucleotide excision repairRisk assessment

Identifiers

PMID42081182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.