ArticleAnnals of hematology2026
High-dose ruxolitinib (25 mg twice daily) in myelofibrosis: feasibility, safety, and long-term treatment exposure in a real-world cohort.
Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRuxolitinib is standard first-line therapy for symptomatic myelofibrosis (MF). In real-world practice, dose reductions are common, and the impact of maintaining higher dose intensity over time remains incompletely characterized-particularly for patients escalated to 25 mg twice daily (50 mg/day; full dose).
methodsWe conducted a single-center retrospective cohort study of consecutive MF patients (2015-2025) who received 25 mg BID at least once during their treatment course. Data were extracted from a structured institutional database linking baseline (DEMOGRAPHY) and visit-level longitudinal data (HISTORY), including dosing, supportive care, infections, transfusions, and spleen measurements. Dose-intensified exposure was defined as 40 mg/day or higher and was used to anchor t0 (first visit at 40 mg/day or higher), while full-dose exposure specifically referred to the approved maximum of 50 mg/day (25 mg twice daily). FRAC_EQ50 quantified sustained full-dose exposure as the fraction of visits at 50 mg/day. Analyses were descriptive.
resultsTwenty-four patients were included, with a median follow-up of 60.9 months from ruxolitinib initiation. Based on FRAC_EQ50, 11/24 patients were classified as high-intensity (FRAC_EQ50 0.50-1.00), 6/24 as intermediate (0.10-0.49), and 7/24 as minimal (below 0.10). For spleen-response analyses, baseline was defined as the first ultrasound spleen length recorded after t0 and was available in 22/24 patients; spleen response was evaluable in 21/24 (one patient lacked a follow-up ultrasound with spleen length in cm; two had no evaluable post-baseline spleen assessments). Spleen length decreased in 17/21 evaluable patients (81.0%), while hematologic toxicities and supportive-care needs remained manageable across intensity groups. Four deaths occurred during follow-up, including one fatal COVID-19 case temporally associated with abrupt ruxolitinib discontinuation during ICU intubation.
conclusionsIn selected MF patients, escalation to 25 mg BID with sustained full-dose intensity appears feasible in routine practice, with durable treatment exposure and manageable safety. These real-world data support further multicenter efforts to better characterize longitudinal dose exposure and its potential clinical implications, without implying causal relationships.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.