Evidence map›Paper›PMID 42080918›Full record

ArticleSurgery today2026

Preoperative D-dimer as a predictor of venous thromboembolism after laparoscopic gastric and colorectal cancer surgery: findings from the EnoLap trial.

Yosuke Ohno, Nobuki Ichikawa, Tadashi Yoshida, Shigenori Homma, Ryoichi Yokota, Yoshiaki Maeda, Kengo Shibata, Ken Imaizumi, Shunji Sano, Takahisa Ishikawa and 4 more

Abstract read
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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yosuke OhnoDepartment of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Nobuki IchikawaDepartment of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan. n_ichi@pop.med.hokudai.ac.jp.ORCID http://orcid.org/0000-0002-8934-9684
Tadashi YoshidaDepartment of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Shigenori HommaDepartment of Surgery, Sapporo-Kosei General Hospital, Kita-3, Higashi-8-5 Chuoku, , Sapporo, Hokkaido, 060-0033, Japan.
Ryoichi YokotaDepartment of Surgery, Sunagawa City Medical Center, Nishi ~4, Kita -3-1-1, Sunagawa, Hokkaido, 073-0196, Japan.
Yoshiaki MaedaDepartment of Gastrointestinal Surgery, National Hospital Organization Hokkaido Cancer Center, Kikusui-4-2, Shiroishiku, Hokkaido, 003-0804, Japan.
Kengo ShibataDepartment of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Ken ImaizumiDepartment of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Shunji SanoDepartment of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Takahisa IshikawaDepartment of Surgery, Asahikawa-Kosei General Hospital, Ichijodori-24-111, Asahikawa, Hokkaido, 078-8211, Japan.
Hiroki ShomuraJapan Community Health Care Organization Hokkaido Hospital, Nakanoshima-1-8 Toyohiraku, Sapporo, Hokkaido, Japan.
Kazuhito UemuraTomakomai City Hospital, Shimizucho-1-5-20, Tomakomai, Hokkaido, 053-8567, Japan.
Hirofumi KamachiDepartment of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Akinobu TaketomiDepartment of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVenous thromboembolism (VTE) is a potentially serious complication after surgery for gastrointestinal cancer; however, its risk factors following laparoscopic surgery remain unclear. This study aimed to identify the risk factors for postoperative VTE in patients undergoing laparoscopic gastrectomy or colectomy.

methodsWe analyzed data, retrospectively, from patients enrolled in the multicenter randomized EnoLap-CG trial, who underwent laparoscopic gastrectomy or colectomy. All patients underwent protocol-mandated contrast-enhanced computed tomography (CT) on postoperative day (POD) 7 to screen for VTE.

resultsPostoperative VTE was identified in 19 (4.6%) of 410 patients. The preoperative D-dimer level was significantly higher in the VTE group than in the no- VTE group (1.40 µg/mL vs. 0.76 µg/mL; p < 0.01). The incidence of VTE was higher in women than in men (7.2% vs. 2.9%; p = 0.05). Multivariate logistic regression analysis demonstrated that an elevated preoperative D-dimer level (OR, 1.89; 95% CI, 1.28-2.80; p < 0.01) and female sex (OR, 2.64; 95% CI, 1.02-6.85; p < 0.01) were independent risk factors for VTE.

conclusionsAn elevated preoperative D-dimer level and female sex are independent risk factors for postoperative VTE after laparoscopic gastric and colorectal cancer surgery.

Indexed as

ColectomyColorectal NeoplasmsFibrin Fibrinogen Degradation ProductsGastrectomyLaparoscopyPostoperative ComplicationsStomach NeoplasmsVenous ThromboembolismAgedBiomarkersFemaleHumansIncidenceMaleMiddle AgedPredictive Value of TestsBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment DD-dimerGastrointestinal NeoplasmsLaparoscopic SurgeryRisk FactorsVenous Thromboembolism

Identifiers

PMID42080918

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.