Evidence map›Paper›PMID 42080873›Full record

ArticlePsychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors2026

Use of cannabis to regulate negative affect in pregnancy: Bidirectional findings from an ecological momentary assessment study.

Rachel L Gunn, Lindy K Howe, Ami Ikeda, Alexander W Sokolovsky, Jane Metrik, Cynthia L Battle, Lauren Micalizzi

Abstract read
In one paragraph

Article in Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rachel L GunnCenter for Alcohol and Addiction Studies, Brown University, School of Public Health.ORCID 0000-0001-5244-1105
Lindy K HoweCenter for Alcohol and Addiction Studies, Brown University, School of Public Health.ORCID 0000-0002-8878-2814
Ami IkedaDepartment of Psychiatry and Human Behavior, Brown University.
Alexander W SokolovskyCenter for Alcohol and Addiction Studies, Brown University, School of Public Health.
Jane MetrikCenter for Alcohol and Addiction Studies, Brown University, School of Public Health.
Cynthia L BattleDepartment of Psychiatry and Human Behavior, Brown University.
Lauren MicalizziCenter for Alcohol and Addiction Studies, Brown University, School of Public Health.

Funding

Using wearables and EMA to examine the links between cannabis and depressionP20GM130414 · NIGMS · BROWN UNIVERSITY · PI Cara Murphy · 2019 to 2026
$22.0M
Substance Abuse Intervention/Outcome Research TrainingT32DA016184 · NIDA · BROWN UNIVERSITY · PI Damaris J. Rohsenow, JENNIFER W. TIDEY · 2003 to 2026
$6.1M
Prenatal Tobacco Exposure: Self-Regulatory Pathways to Externalizing BehaviorsK01DA048135 · NIDA · BROWN UNIVERSITY · PI MICALIZZI, LAUREN GIOIA · 2020 to 2024
$905k
National Institutes of Health; National Institute of General Medical SciencesNIDA NIH HHS K01 DA048135NIDA NIH HHS T32 DA016184NIGMS NIH HHS P20 GM130414
6 · The paper itself

Abstract

objectivePrenatal cannabis use is increasing in the United States, despite evidence of potential harms to pregnant individuals and their offspring. Elevated rates of anxiety and depression among those who use cannabis during pregnancy suggest that mental health difficulties may contribute to prenatal cannabis use. In line with the affect regulation hypothesis, many pregnant individuals endorse using cannabis to manage mood. However, no studies have examined this relationship in real time. Moreover, the acute effects of cannabis on mood during pregnancy remain understudied, limiting knowledge of whether negative affect (NA) relief reinforces continued use. Addressing these gaps, the present study examines the relationship between momentary NA and cannabis use in pregnant adults and explores the effect of cannabis on NA.

methodsParticipants (

resultsGeneralized linear mixed-effects models tested whether momentary ratings of depression, anxiety, and irritability predicted subsequent cannabis use (Aim 1), and linear mixed-effects models tested whether cannabis use predicted subsequent changes in NA (Aim 2). Aim 1 results indicated that greater levels of NA (momentary depression, anxiety, and irritability) were associated with greater odds of using cannabis. Aim 2 results suggest cannabis use was followed by reductions in depression, anxiety, and irritability, reflecting short-term NA relief.

conclusionsFindings provide the first real-time evidence supporting the affect regulation hypothesis in pregnancy and highlight the potential reinforcing role of NA relief in sustaining prenatal cannabis use. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

Identifiers

PMID42080873
PMCPMC13208008

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.