Evidence map›Paper›PMID 42080838›Full record

ArticlePain practice : the official journal of World Institute of Pain2026

Awake Percutaneous Cervical Cordotomy in Patients With Cancer: A Technical Report.

Adinda P Pradhana, Hans Timmerman, Egbert J M Klarenbeek, Martijn L Verstraaten, Ruud Stellema, Anna K L Reyners, André P Wolff

Abstract readCase Reports
In one paragraph

Article in Pain practice : the official journal of World Institute of Pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adinda P PradhanaDepartment of Anesthesiology, Pain Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0001-7249-6170
Hans TimmermanDepartment of Anesthesiology, Pain Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-6082-9043
Egbert J M KlarenbeekDepartment of Anesthesiology, Pain Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0009-0001-2051-7520
Martijn L VerstraatenDepartment of Anesthesiology, Pain Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0009-0004-1896-3670
Ruud StellemaDepartment of Anesthesiology, Pain Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0009-0000-7622-6055
Anna K L ReynersDepartment of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0003-1678-7816
André P WolffDepartment of Anesthesiology, Pain Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0001-6240-3903

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPercutaneous cervical cordotomy (PCC) is a minimally invasive radiofrequency procedure for intractable unilateral cancer pain. Commonly performed under conscious sedation, awake PCC enables real-time patient feedback, potentially improving targeting precision and expanding eligibility for patients in whom sedation poses risks. METHOD AND TECHNIQUE: This article presents the structured protocol for awake PCC implemented at our center, including pre-procedural training, positioning, fluoroscopic guidance, impedance monitoring, sensory and motoric testing, lesioning strategy, and aftercare. The key principle is to create the smallest effective lesion, applied incrementally until spinothalamic tract disruption is confirmed. DISCUSSION: In our experience, awake PCC enables precise targeting and has yielded up to 90% success in pain relief. The approach requires substantial preparation, including training for both patient and team to ensure cooperation, clear communication, and tolerance of brief intraoperative discomfort. Although these demands can be challenging, we have found awake PCC to be a safe and effective last-resort option for patients facing devastating pain.

conclusionThis technical note provides a practical and stepwise approach to awake PCC. It may assist clinicians in adopting or refining the technique.

Indexed as

Cancer PainCervical CordCordotomyWakefulnessHumanscordotomyneoplasmsneurosurgical procedurespain managementpalliative carespinothalamic tract

Identifiers

PMID42080838
PMCPMC13138373

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.