ArticleThe FEBS journal2026
Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes.
Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
During liver fibrosis, hepatocytes respond to progressive increases in tissue stiffness by undergoing cytoskeletal reorganisation. This has important consequences such as immune cell infiltration, mainly triggered by the activation of YAP and TAZ proteins. However, other proteins that respond to mechanical modifications remain poorly characterised; in particular, the myocardin-related transcription factors A and B (MRTFs). Here, we referred to these four proteins as mechanical responsive transcriptional cofactors (MRTcoF). We analysed the regulation of MRTcoF proteins in fibrotic livers induced by carbon tetrachloride (CCl
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