ArticleClinical and translational science2026
Predictors of Clinical Trial Participation Among Older U.S. Adults With Multimorbidity: A Cross-Sectional Survey.
Article in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Older adults, women, and minorities are under-represented in clinical trials. Our objective was to identify characteristics predicting participation in clinical trials of medications in a diverse sample of older adults; and, secondarily, identify current participation motivators and barriers and trial preferences. A cross-sectional U.S. community convenience sample survey of adults > 65 years with > 3 chronic medical conditions querying attitudes about participation in clinical trials was conducted from March 2023-October 2024 in English and Spanish. Formats were yes/no or three-point Likert scale answers. Multivariable logistic regression identified characteristics with higher likelihood of trial participation. Surveys were from 2176 older adults (White (50.3%), Black/African American (18.5%), Hispanic/Latino (17.7%), Asian (13.5%) aged 73.1 ± 6.1 years (mean, SD), 52% women,one 4.1 ± 1.9 medical conditions; taking 7.4 ± 3.2 medications. Characteristics with higher likelihood of trial participation were higher income (1.36, 0.93-1.99; Odds Ratio, 95% Confidence Interval), educational status (1.88, 1.12-3.0), greater health literacy (2.07, 1.29-3.3), having cancer (1.49, 1.11-1.99) or chronic pain (1.55, 1.17-2.06), Black/African American race (1.44, 1.02-2.02) or Hispanic/Latino race/ethnicity (1.55, 1.11-2.16). Females had lower likelihood of participation (0.66, 1.29-3.32) as did age 75 and above (0.67, 0.50-0.92). Disincentives in women were potential side effects, placeboes, visit travel > 1 h, and video visits. Prior participants and nonparticipants were more likely to consider participation after physician recommendation (92% and 76.4%, respectively). Better care would motivate the highest percentage of all respondents. Education about trials including possible benefits, addressing concerns of women, physician involvement during recruitment and trials with in-person visits may increase representative enrollment.
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