Chronic intermittent hypoxia exacerbates hepatic steatosis in a microbiota-dependent manner in lean mice.

Xiaoman Zhang, Anyuan Zhong, Yupu Liu, Jianyin Zou, Meizhen Gu, Xiaoyue Zhu, Huajun Xu, Shankai Yin

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Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Xiaoman Zhang *Department of Otolaryngology Head and Neck Surgery and Otolaryngology, Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0002-4450-1926

Anyuan Zhong *Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Yupu LiuDepartment of Otolaryngology Head and Neck Surgery and Otolaryngology, Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-0865-4669

Jianyin ZouDepartment of Otolaryngology Head and Neck Surgery and Otolaryngology, Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-1351-7175

Meizhen GuDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID 0009-0004-9388-7161

Xiaoyue ZhuDepartment of Otolaryngology Head and Neck Surgery and Otolaryngology, Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-3277-8071

Huajun XuDepartment of Otolaryngology Head and Neck Surgery and Otolaryngology, Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Shankai YinDepartment of Otolaryngology Head and Neck Surgery and Otolaryngology, Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

Ministry of Science and Technology of the People's Republic of China 2021ZD0201900National Natural Science Foundation of China 82071029National Natural Science Foundation of China 82071030Science and Technology Commission of Shanghai Municipality 18DZ2260200

6 · The paper itself

Abstract

Chronic intermittent hypoxia (CIH), a hallmark pathological feature of obstructive sleep apnea (OSA), is extensively linked to hepatic steatosis in high-fat-diet-induced mice. However, the association between CIH and hepatic steatosis in lean mice, as well as the potential involvement of gut microbiota-related mechanisms, remains poorly understood. Four hundred participants in the Shanghai Sleep Health Study were included to assess the association between apnea-hypopnea index (AHI) and hepatic steatosis index (HSI). To characterize CIH-associated phenotypes and explore microbiota-related alterations in lean mice, liver histology, inflammatory cytokine profiling, metagenomic sequencing with antibiotic intervention, plasma untargeted metabolomics, and liver transcriptomics were performed. As a result, AHI was positively associated with HSI in non-obese participants. In lean mice, 16-week CIH alone induced hepatic steatosis and inflammation, accompanied by significant alterations in gut microbiota composition. Antibiotic treatment attenuated hepatic steatosis and inflammation in 16-week CIH-exposed mice. Metagenomic analysis revealed CIH-associated depletion of

Indexed as

Fatty LiverGastrointestinal MicrobiomeHypoxiaAnimalsDisease Models, AnimalHumansLiverMaleMetabolomicsMiceMice, Inbred C57BLSleep Apnea, Obstructivehepatic steatosisinflammationintermittent hypoxiaobstructive sleep apnea

Identifiers

PMID42080548

DOI10.1128/msystems.00163-26

PMCPMC13289086

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.