ArticleAnnals of clinical and translational neurology2026
MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children.
Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A Lethal Progressive Neuroinflammation Disguised as MOGAD Revealing a Final Diagnosis of Griscelli Syndrome.Annals of clinical and translational neurology · 2026Article
- Reply to: A Lethal Progressive Neuroinflammation Disguised as MOGAD Revealing a Final Diagnosis of Griscelli Syndrome: Regarding: MOGAD is the Most Common Cause of Isolated Optic Neuritis in Children.Annals of clinical and translational neurology · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
objectivesThe study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first-time pediatric ON in the post-MOG-IgG era.
methodsThis was a single-center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first-time ON between 2018-2024, with follow-up data collected through 2025. Inclusion criteria required monocular or binocular subacute vision loss with supportive paraclinical signs. Subjects were excluded if they had a prior history of demyelinating disease or extra-orbital demyelinating lesions on initial brain/spine MRI. Primary outcomes were the proportion of MOG-IgG seropositivity, retinal nerve fiber layer thickness, and visual acuity at onset and most recent follow-up.
resultsOf 73 children with ON, 38 met criteria for isolated first-time ON. Etiologies included MOGAD (n = 27, 71.1%) and idiopathic/monophasic (n = 9, 23.7%), while none of the 38 subjects were later diagnosed with multiple sclerosis. MOGAD-ON was associated with less severe vision loss at presentation (p < 0.01) compared to idiopathic cases. At most recent follow-up, both groups achieved excellent functional recovery, yet both demonstrated significant retinal nerve fiber layer thinning from ON presentation. Linear regression revealed worse presenting LogMAR significantly correlated to thinner follow-up RNFL (F(1,18) = 8.467, R
interpretationIn isolated pediatric ON, no patients were diagnosed with MS, and MOGAD is the predominant etiology. The linear correlation between initial LogMAR and subsequent RNFL atrophy suggests a permanent reduction in neurological reserve dependent on the degree of functional severity at ON onset.
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