ArticleAnnals of medicine2026
Post-task resting-state fMRI of walking-related neural activity in patients with stroke: immediate and delayed brain network dynamics.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWalking impairments post-stroke are common but studying their neural basis with fMRI is difficult due to motion constraints. This study used post-task resting-state residual activity (PTRRA) to investigate walking-related neural activity without in-scanner movement.
methodsTen patients with subcortical ischemic stroke and ten matched healthy controls underwent two resting-state fMRI sessions: one immediately after overground walking, and another after a 20-minute delay. Clinical assessments included Fugl-Meyer Assessment and Timed Up-and-Go Test (TUGT). Analyses included ALFF, functional connectivity (FC), and graph theory.
resultsSignificant group × time interactions showed that stroke patients had increased ALFF in the contralesional primary somatosensory cortex (S1) during the delayed session. This increase inversely correlated with TUGT scores (r = -0.677,
conclusionIncreased contralesional S1 activation and its enhanced connectivity with bilateral motor areas may reflect adaptive changes supporting post-stroke balance. The PTRRA method proved feasible for capturing post-walk neural activity and may be useful for assessing large-scale network dynamics after stroke.
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