ArticleProtein science : a publication of the Protein Society2026
The interplay between the pyramidalization of carbonyl carbons and the n → π* interactions in biomolecules.
Article in Protein science : a publication of the Protein Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The interplay between the pyramidalization of carbonyl carbons and the n → π* interactions in biomolecules.Protein science : a publication of the Protein Society · 2026Article
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Abstract
The structural preferences of biomolecules arise from a delicate balance of different forces whose identification and quantification are challenging. Studies conducted over the last two decades have shown that the n → π* interaction formed between consecutive carbonyl groups plays a crucial role in stabilizing biomolecules, which exhibit a wide range of chemical properties and structural complexities. These studies also demonstrate that the n → π* interaction relies heavily on the pyramidalization of the carbonyl group, which accepts electrons, to such an extent that pyramidalization has frequently been considered a signature of this interaction. Here, statistical surveys of different structural databases aimed at evaluating the precise relationship between the n → π* interaction and the carbonyl carbon pyramidalization (θ
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