ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2026
miR-3678-3p Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating Phosphatase and Tensin Homolog.
Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/Aims: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy characterized by high invasiveness. The current study aimed to evaluate the role of miR-3678-3p in ESCC and its potential mechanisms. Materials and Methods: The study included 109 ESCC patients. The miR-3678-3p expression in ESCC tissues and cells was quantified. The association between miR-3678-3p and ESCC severity and adverse prognosis was evaluated. The target relationship between miR- 3678-3p, phosphatase and tensin homolog (PTEN) was confirmed. The effects of miR 3678-3p and PTEN on ESCC cell function were analyzed. Results: ESCC tissues and cells exhibited elevated expression of miR-3678-3p. Elevated miR-3678-3p expression was significantly associated with malignant clinical features in ESCC, including larger tumor size, advanced tumor-node-metastasis staging, higher lymph node metastasis, and poor tumor differentiation. High miR-3678-3p expression served as a predictor of shorter overall survival. miR-3678-3p targeted and regulated PTEN. miR-3678-3p knockdown significantly suppressed the malignant progression of ESCC cells, whereas silencing of PTEN reversed these effects. miR-3678-3p and PTEN jointly participated in the development of ESCC. Conclusion: miR-3678-3p serves as a promising prognostic marker for predicting the severity and adverse outcomes of ESCC. miR- 3678-3p promotes ESCC progression by targeting PTEN.
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