Evidence map›Paper›PMID 42080228›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Pre-analytical guidelines for blood and CSF Biomarkers 2025: Recommendations from the NACC ADRC Biofluid Biomarker Best Practices Workgroup.

Timothy E Van Meter, Edward N Wilson, Fanny Elahi, Robert A Rissman, Argentina Lario Lago, Kelley Faber, Kathryn Gauthreaux, Ricardo Osorio, Matthew Perkins, Nora Gray and 12 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Timothy E Van MeterBRAINBox Solutions, , Inc., Richmond, Virginia, USA.ORCID 0000-0002-5524-4251
Edward N WilsonDepartment of Neurology & Neurological Sciences, Stanford University, Stanford, California, USA.
Fanny ElahiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Robert A RissmanDepartment of Physiology and Neuroscience, Alzheimer's Therapeutic Research Institute, Keck School of Medicine of the University of Southern California, San Diego, California, USA.ORCID 0000-0001-9245-8278
Argentina Lario LagoMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Kelley FaberNCRAD, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kathryn GauthreauxNational Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
Ricardo OsorioNathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Matthew PerkinsDepartment of Child Psychiatry, Center for the Advancement of Children's Mental Health, Columbia University, New York, New York, USA.
Nora GrayOregon ADRC, Oregon Health and Sciences University, Portland, Oregon, USA.
Jill MorrisKU ADRC, KU Clinical Research Center, Fairway, Kansas, USA.
Andy LiuDuke University School of Medicine, Department of Neurology, Durham, North Carolina, USA.
Hannah StockwellNational Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
Walter KukullWisconsin ADRC, Madison, Wisconsin, USA.
Rachael WilsonDepartment of Neurology, University of California, Davis, Sacramento, California, USA.ORCID 0000-0002-7679-6282
Thomas S WingoDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA.ORCID 0000-0002-4362-2593
Nicholas M KanaanNCRAD, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kristen RussNational Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
Donna WilcockNathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Sarah A BiberNational Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
Lynn M BekrisDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, University of Washington Alzheimer's Disease Research Center, Seattle, Washington, USA.ORCID 0000-0002-2747-7672
Thomas K KarikariDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1422-4358

Funding

National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Teresa Gomez-Isla · 2019 to 2026
$36.5M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Barbara Brigitta Bendlin · 2019 to 2026
$34.5M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5M
Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Carolyn Wei Zhu · 2020 to 2026
$31.0M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER, CHRISTOPHER H VAN DYCK · 2020 to 2026
$30.2M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Miguel Arce · 2020 to 2026
$30.1M
Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI C. Elizabeth Shaaban · 2020 to 2026
$29.4M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0M
NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072973NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072979NIA NIH HHS P30 AG086401NIA NIH HHS P30 AG086404NIA NIH HHS R01 AG079280NIA NIH HHS U24 AG072122
6 · The paper itself

Abstract

The Biofluid Biomarkers Best Practices Workgroup of the National Alzheimer's Coordinating Center-Alzheimer's Disease Research Center (ADRC) Biomarker Core Steering Committee was convened to update pre-analytical handling guidelines for biofluid biomarkers, focusing on cerebrospinal fluid (CSF) and blood. We reviewed current literature pertinent to best practices for biomarker studies and surveyed the ADRCs for biomarker analytes, platforms, and protocols used at each center. Across 37 ADRCs, 16 CSF and 28 plasma/serum analytes were reported to be studied at multiple centers. The pre-analytical handling steps and concerns related to each, as supported by empirical studies and expert opinion, were integrated to generate a revised guideline document. The guideline aimed to standardize steps in biospecimen and biomarker analyte collection, storage, and pre-analytical handling across the ADRCs. The 2025 ADRC guidelines represent the current working knowledge on biomarker best practices, providing guidance and harmonized protocols, and promoting robust analysis and reporting of composite data.

Indexed as

Alzheimer DiseaseBiomarkersPractice Guidelines as TopicSpecimen HandlingHumansBiomarkersAlzheimer's diseasebest practicesbiomarkerbloodcerebrospinal fluid

Identifiers

PMID42080228
PMCPMC13137281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.