ArticlePatient preference and adherence2026
Determinants of Medication Non-Adherence in 1,750 Indonesian Adults with Chronic Diseases: A Nationwide Cross-Sectional Study.
Article in Patient preference and adherence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Barriers and Facilitators of Compliance with Iron-Folic Acid Supplementation Among Pregnant Women in Southern Afghanistan: A Qualitative Study.Patient preference and adherence · 2026Article
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6 authors.
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Abstract
Purpose: Medication adherence is critical for effective chronic disease management, yet non-adherence remains a major challenge. Current evidence on medication adherence in Indonesia is constrained by small sample sizes, narrow geographic scope, and a failure to adequately account for the complex interplay of social, economic, and cultural factors. This study aimed to identify factors associated with medication non-adherence in patients with chronic diseases in Indonesia. Methods: This nationwide cross-sectional study was carried out across 34 provinces in Indonesia during April - November 2024. Participants were patients aged 20-74 years diagnosed with at least one chronic disease. Medication non-adherence was assessed through an online and offline self-reported survey. Data was analyzed using multivariable logistic regression, with Odds Ratio (OR) and 95% Confidence Interval (CI) reported. Results: Among 1,750 participants, 957 (54.7%) were adherent and 793 (45.3%) were non-adherent. Non-adherence was most prevalent in digestive diseases (371/541; 68.6%) and psychiatric disorders (37/52; 71.2%). In multivariable logistic regression, younger age (20-30 years: aOR 4.53, 95% CI 2.90-7.09), residence in Java and Bali (aOR 3.21, 95% CI 1.85-5.56), lower income (<IDR 1,500,000: aOR 2.08, 95% CI 1.48-2.92), absence of health insurance (aOR 1.43, 95% CI 1.06-1.92), self-perceived health status (healthy: aOR 2.48, 95% CI 1.63-3.77), and healthcare-seeking behavior (self-medication: aOR 3.36, 95% CI 2.37-4.77; no treatment: aOR 8.77, 95% CI 4.98-15.44) were significantly associated with non-adherence. Conclusion: Medication non-adherence affected nearly half of Indonesian patients with chronic diseases. Strengthening health insurance coverage, addressing financial and geographic disparities, and implementing targeted education strategies, including gender-sensitive approaches that address financial barriers among women and health perception-related factors among men, are essential to improve medication adherence.
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