ArticleRSC advances2026
New benzochromene-based compounds as potential EGFR-TK inhibitors: synthesis, anti-proliferative activity, molecular docking studies, and ADME profiles.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Synthesis, anti-proliferative evaluation, DFT,RSC advances · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we report the synthesis and biological evaluation of a novel series of benzochromene and benzochromenopyrimidine derivatives employingenaminonitrile compound 1 as a key synthetic precursor. The structures of the synthesized compounds were elucidated using comprehensive analytical and spectroscopic techniques. The antiproliferative activities of the prepared derivatives were evaluated against three cancer cell lines, HCT-116, MCF-7, and HepG2, as well as the normal human lung fibroblast cell line, WI-38, using the MTT assay, with doxorubicin used as the standard reference drug. Among the tested derivatives, compounds 6, 7, and 10 demonstrated notable antiproliferative activity against all examined cancer cell lines. In particular, compound 7 exhibited potent cytotoxic effects, with IC
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.