ArticleInternational journal of medical sciences2026
Causal Association Between Body Mass Index and Kidney Stone Disease in Taiwanese: A Mendelian Randomization Study.
Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Introduction: Kidney stone disease (KSD) is a common urological disorder with an increasing incidence worldwide. Previous observational studies have reported an association between body mass index (BMI) and KSD; however, the causal relationship remains uncertain, particularly in Asian populations. This study aimed to investigate the causal effect of BMI on KSD risk in Taiwanese individuals using a Mendelian randomization (MR) approach. Materials and Methods: BMI-associated single nucleotide polymorphisms (SNPs) were identified through a literature review and validated in Taiwanese cohorts (n = 107,191). Significant SNPs ( Results: A total of 17 BMI-associated SNPs validated in the Taiwanese cohort were used as instrumental variables in the MR analysis. The penalized IVW model demonstrated a significant positive association between genetically predicted BMI and KSD risk (OR = 2.16, 95% CI: 1.22-3.81, Conclusion: Our findings provide genetic evidence supporting a causal association between higher BMI and increased KSD risk in Taiwanese individuals, suggesting that weight management may play an important role in KSD prevention. Further studies are needed to investigate the underlying biological mechanisms, population-specific genetic susceptibilities, and effective preventive strategies for obesity-related KSD.
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