Evidence map›Paper›PMID 42080010›Full record

ArticleChemical science2026

A reflection on synthesis by extrusion ten years on: achievements, challenges and opportunities for solvent-free, sustainable, continuous chemical manufacturing.

Deborah E Crawford, Stuart L James

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Deborah E CrawfordSchool of Chemistry, University of Birmingham Edgbaston Birmingham B15 2TT UK d.e.crawford@bham.ac.uk.ORCID https://orcid.org/0000-0003-2579-7987
Stuart L JamesSchool of Chemistry and Chemical Engineering, Queen's University Belfast David Kier Building, Stranmillis Road Belfast BT9 5AG UK s.james@qub.ac.uk.ORCID https://orcid.org/0000-0002-6554-0345

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2015, we and colleagues published an article reporting that it was possible to synthesise metal organic frameworks (MOFs) and discrete coordination complexes by Twin Screw Extrusion (TSE) - a remarkably efficient, continuous and potentially scalable synthesis technique that required little or no solvent (D. Crawford, J. Casaban, R. Haydon, N. Giri, T. McNallyand S. L. James,

Identifiers

PMID42080010
PMCPMC13133924

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.