Evidence map›Paper›PMID 42079937›Full record

ArticleJTCVS open2026

Aortic reinterventions following reoperative frozen elephant trunk aortic arch replacement for the treatment of residual type A aortic dissection.

Joseph Kletzer, Sergey Leontyev, Zara Dietze, Michael Borger, Maximilian Luehr, Christopher Gaisendrees, Tim Berger, Julia Dumfarth, Michael Grimm, Andreas Vötsch and 5 more

Abstract read
In one paragraph

Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Joseph KletzerDepartment of Cardiovascular Surgery, Heart Centre, Freiburg University, Faculty of Medicine, Albert Ludwig's University of Freiburg, Freiburg, Germany.
Sergey LeontyevUniversity Department for Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany.
Zara DietzeUniversity Department for Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany.
Michael BorgerUniversity Department for Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany.
Maximilian LuehrDepartment of Cardiac Surgery, Heart Center of the University of Cologne, Cologne, Germany.
Christopher GaisendreesDepartment of Cardiac Surgery, Heart Center of the University of Cologne, Cologne, Germany.
Tim BergerDepartment of Cardiovascular Surgery, Heart Centre, Freiburg University, Faculty of Medicine, Albert Ludwig's University of Freiburg, Freiburg, Germany.
Julia DumfarthUniversity Clinic for Cardiac Surgery, Medical University Innsbruck, Innsbruck, Austria.
Michael GrimmUniversity Clinic for Cardiac Surgery, Medical University Innsbruck, Innsbruck, Austria.
Andreas VötschDepartment of Cardiac Surgery, Paracelesus Medical University, Salzburg, Austria.
Philipp Krombholz-ReindlDepartment of Vascular and Endovascular Surgery, Paracelesus Medical University, Salzburg, Austria.
Felix NagelDepartment of Cardiac Surgery, University Hospital St Pölten, Karl Landsteiner University, St Pölten, Austria.
Andrea FinsterDepartment of Cardiac Surgery, University Hospital St Pölten, Karl Landsteiner University, St Pölten, Austria.
Martin CzernyDepartment of Cardiovascular Surgery, Heart Centre, Freiburg University, Faculty of Medicine, Albert Ludwig's University of Freiburg, Freiburg, Germany.
Maximilian KreibichDepartment of Cardiovascular Surgery, Heart Centre, Freiburg University, Faculty of Medicine, Albert Ludwig's University of Freiburg, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The optimal treatment strategy for residual Type A aortic arch dissections after ascending aortic replacement remains debated. This study evaluated the frequency and outcomes of aortic reinterventions after reoperative total arch replacement with frozen elephant trunk (FET) implantation for residual Type A aortic dissection. Methods: Between April 2015 and March 2025, 116 patients underwent elective redo arch replacement using the FET technique for residual Type A dissection at 6 European aortic centers. Incidence, procedural characteristics, and outcomes of patients requiring downstream aortic reinterventions were retrospectively analyzed. Results: In-hospital mortality following FET implantation was 5% (n = 6). Among 110 hospital survivors, 43 patients (39%) required at least 1 aortic reintervention within 48 months: thoracic or abdominal endovascular aortic repair in 36 (80%), graft replacement in 2 (4.4%), and open thoracoabdominal replacement in 4 (9%). No spinal cord injury or disabling stroke occurred postoperatively; 3 patients (6%) died within 30 days of reintervention. After discharge, a second reintervention was necessary in 7 patients (16%), involving endovascular repair in 4 (57%) and open thoracoabdominal replacement in 3 (43%). The cumulative risk of any reintervention was 31.0% (95% CI, 23.1%-40.6%) at 2 years and 55.4% (95% CI, 42.0%-66.9%) at 4 years, whereas overall survival after FET was 87.8% (95% CI, 81.1%-95.1%) and 82.0% (95% CI, 72.1%-93.3%) at 2 and 4 years, respectively. Conclusions: Reoperative arch replacement with FET yields favorable survival but is accompanied by a substantial need for staged downstream aortic reinterventions, most of which can be managed endovascularly, underscoring the importance of structured long-term imaging surveillance.

Indexed as

aortic archFrozen elephant trunkredo surgeryType A dissection

Identifiers

PMID42079937
PMCPMC13131187

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.