ArticleFrontiers in neurology
Association between monocyte-to-high-density lipoprotein cholesterol ratio and stroke: a propensity score matched cross-sectional study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Stroke is one of the leading causes of death and long-term disability worldwide, and chronic inflammation plays a central role in its pathogenesis. The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) integrates pro-inflammatory activity and anti-atherosclerotic capacity, but its association with stroke risk in the general population remains unclear. This study aims to explore the relationship between MHR and stroke among U.S. adults. Methods: In this cross-sectional study, we leveraged data from the 1999-2020 National Health and Nutrition Examination Survey (NHANES). Multivariable logistic regression models were employed to examine the relationship between the MHR and stroke risk. Restricted cubic spline (RCS) analysis assessed potential non-linear dose-response relationships, while subgroup analyses evaluated its robustness. Propensity score matching (PSM) was applied to minimize confounding bias through sample refinement. Results: The analytical cohort encompassed 43,321 participants, including 1,583 individuals with physician-diagnosed stroke. Following PSM, the non-stroke comparator group was refined to 4,719 subjects. In the fully adjusted multivariable model, elevated MHR demonstrated a statistically significant association with stroke predisposition [Odds ratio (OR) = 1.517; 95% Confidence interval (CI):1.096-2.099]. RCS regression confirmed a linear dose-response gradient between MHR and stroke risk ( Conclusion: In this nationally representative cross-sectional study, higher MHR levels were associated with an increased risk of stroke. Although these findings suggest that MHR may be a potential biomarker related to stroke risk, further prospective studies are required to validate its temporal relationship and clinical applicability.
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