Evidence map›Paper›PMID 42079756›Full record

ArticleFrontiers in ophthalmology2026

Four-dimensional ultrasound versus torsional ultrasound phacoemulsification in cataracta nigra: a single-nucleus

Rosa Giglio, Daniele Tognetto

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07756385 (Comparison of Ultrasound Efficiency and Early Postoperative Outcomes of Two Phacoemulsification Systems), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07756385 narecruitingnot on this map

Comparison of Ultrasound Efficiency and Early Postoperative Outcomes of Two Phacoemulsification Systems (UNITY VCS 4D Phaco and Centurion With Active Sentry Probe): A Randomized Contralateral Eye Study

TypeinterventionalSponsorUniversity Hospital Sveti DuhRan2026 to 2026Enrolled30ConditionsCataract SurgeryArmsUNITY VCS SYSTEM ®, CENTURION VISION SYSTEM ®
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rosa GiglioDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Daniele TognettoDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cataracta nigra, an extremely dense nuclear cataract, often requires prolonged ultrasound use during phacoemulsification, increasing the risk of corneal endothelial injury and incision-site thermal damage. We compared the Alcon UNITY Cataract System using 4-dimensional (4D) ultrasound with the Alcon CENTURION Vision System with torsional ultrasound in an ex vivo cataracta nigra bench model. A single human cataracta nigra nucleus was divided into four fragments; two fragments were emulsified with UNITY and two with CENTURION under identical user-selected console settings (35% power; IOP 36 mmHg; vacuum 450 mmHg; aspiration flow 30 mL/min). Endpoints included emulsification time, effective phaco time (EPT), cumulative dissipated energy (CDE), and qualitative video assessment of fragments behavior. In this single-specimen model, compared with CENTURION, UNITY showed shorter emulsification time (mean 12.0 s vs 43.5 s) and lower console-reported energy indices (mean EPT 4.2 s vs 15.2 s; mean CDE 1.12 percent-seconds vs 15.01 percent-seconds). Video review suggested more continuous fragment engagement with minimal chatter using UNITY, whereas CENTURION more often showed initial fragment repulsion and turbulence. Because EPT and CDE are console-derived, these findings should be interpreted as relative performance under matched user-selected settings rather than equivalent physical energy delivery. These preliminary findings suggest that the 4D ultrasound mode might be associated with improved emulsification efficiency compared to torsional mode in ultra-dense nuclear material. Further studies using additional specimens and clinical cohorts are needed to determine whether these bench findings translate into meaningful surgical benefit.

Indexed as

cataracta nigracumulative dissipated energyex vivo bench studyfour-dimensional ultrasoundphacoemulsificationtorsional ultrasound

Identifiers

PMID42079756
PMCPMC13128589

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.