ArticleFrontiers in cellular and infection microbiology2026
A rabbit model of acute bacteremia and sepsis caused by vancomycin-resistant
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vancomycin-resistant Objectives: To establish a rabbit model of Methods: We established a reproducible rabbit model of acute VREF bacteremia using New Zealand White rabbits ( Results: Infected untreated rabbits exhibited significant weight loss, sustained fever (>40 °C, peaking at 39h), and 20% mortality within 12h. Systemic bacterial dissemination was confirmed in all organs examined, with the spleen showing the highest bacterial load and the liver exhibiting the most severe histopathological damage (necrosis and suppurative inflammation). The mAb 8AP treatment significantly improved clinical outcomes: heart and respiratory rates decreased, and body weight increased compared with untreated infected rabbits. Cytokine profiling showed elevated levels of IL-6, IL-8, and IL-10, consistent with systemic inflammatory response syndrome (SIRS), with the mAb treatment showing a trend toward immune modulation. Conclusions: This model successfully simulates human VREF bacteremia and demonstrates the therapeutic potential of mAb 8AP. The rabbit model provides a clinically relevant platform for evaluating novel immunotherapies for VREF infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.